Document Detail

Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma.
MedLine Citation:
PMID:  18224414     Owner:  NLM     Status:  MEDLINE    
Anemia is one of the characteristics of idiopathic myelofibrosis (IMF), and malignant thymoma is usually associated with various hematologic disorders, including anemia, pancytopenia, and hypogammaglobulinemia. However, the relationship between IMF and malignant thymoma has not been published before. Here, we report a 48-year-old woman who was initially diagnosed of IMF with severe anemia and transfusion dependent. Five years later, malignant thymoma was found when she was examined for chronic cough. After performing extended thymectomy, her anemia dramatically recovered to normal and sustained for 2 years till last follow-up. Her splenomegaly and myelofibrosis were also improved. We hypothesized that her malignant thymoma induced the progression of IMF, especially in anemia.
Ying-Yih Shih; Liang-Tsai Hsiao; Ching-Fen Yang; Yu-Chung Wu; Tzeon-Jye Chiou
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-12-06
Journal Detail:
Title:  International journal of hematology     Volume:  87     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-10-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-9     Citation Subset:  IM    
Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
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MeSH Terms
Anemia / etiology,  surgery*
Bone Marrow / pathology
Middle Aged
Primary Myelofibrosis / complications*
Remission Induction
Thymoma / complications*,  surgery
Thymus Neoplasms / complications*,  surgery

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