Document Detail


Dramatic influence of V beta gene polymorphism on an antigen-specific CD8+ T cell response in vivo.
MedLine Citation:
PMID:  10202004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
According to recent crystallographic studies, the TCR-alpha beta contacts MHC class I-bound antigenic peptides via the polymorphic V gene-encoded complementarity-determining region 1 beta (CDR1 beta) and the hypervariable (D)J-encoded CDR3 beta and CDR3 alpha domains. To evaluate directly the relative importance of CDR1 beta polymorphism on the fine specificity of T cell responses in vivo, we have taken advantage of congenic V beta a and V beta b mouse strains that differ by a CDR1 polymorphism in the V beta 10 gene segment. The V beta 10-restricted CD8+ T cell response to a defined immunodominant epitope was dramatically reduced in V beta a compared with V beta b mice, as measured either by the expansion of V beta 10+ cells or by the binding of MHC-peptide tetramers. These data indicate that V beta polymorphism has an important impact on TCR-ligand binding in vivo, presumably by modifying the affinity of CDR1 beta-peptide interactions.
Authors:
H Bour; O Michielin; P Bousso; J C Cerottini; H R MacDonald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  162     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4647-56     Citation Subset:  AIM; IM; X    
Affiliation:
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
CD4-Positive T-Lymphocytes / immunology,  metabolism
CD8-Positive T-Lymphocytes / immunology,  metabolism*
Epitopes, T-Lymphocyte / genetics,  immunology*
Female
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genes, T-Cell Receptor beta / immunology*
HLA-C Antigens / immunology
Immunodominant Epitopes / immunology,  metabolism
Lymphocyte Activation / immunology
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Molecular Sequence Data
Neoplasm Transplantation
Peptides / immunology,  metabolism
Polymorphism, Genetic / immunology
Receptors, Antigen, T-Cell, alpha-beta / biosynthesis*,  genetics*,  immunology
T-Lymphocyte Subsets / immunology,  metabolism*
Thymus Gland / immunology,  metabolism
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Epitopes, T-Lymphocyte; 0/HLA-C Antigens; 0/HLA-Cw3; 0/Immunodominant Epitopes; 0/Peptides; 0/Receptors, Antigen, T-Cell, alpha-beta

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