| Dramatic effect on oxygenation in patients with severe acute lung insufficiency treated in the prone position. | |
| | |
MedLine Citation:
|
PMID: 9295829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To confirm the positive effect of prone positioning on oxygenation in patients with acute lung insufficiency. DESIGN: Clinical follow-up study. SETTING: The intensive care unit at a tertiary care academic hospital. PATIENTS: Thirteen patients suffering from severe acute lung insufficiency caused by trauma, septicemia, aspiration, and burn injury. Eleven of the patients had severe hypoxia (oxygenation indices [PaO2/FIO2] < or = 80 torr [< or = 10.7 kPa]). Patients > 70 yrs of age were excluded from the study. INTERVENTIONS: Treatment in the prone position without changing other ventilatory settings than FIO2 when saturation increased. MEASUREMENTS AND MAIN RESULTS: Twelve of the 13 patients responded to treatment in the prone position. The patient that did not respond improved her gas exchange when nitric oxide was instituted. She died, however, from a Gram-negative septicemia. No patient needed extracorporeal membrane oxygenation. Apart from the settings of FIO2 when saturation increased, the ventilatory settings were unchanged. In the prone position, the oxygenation index increased (p < .0002) and the alveolar-arterial oxygen gradient, P(A-a)O2, decreased dramatically (p < .0001). CONCLUSIONS: The prone position significantly improves impaired gas exchange due to severe acute lung insufficiency. It is suggested that this treatment is used before more complex modalities. |
| | |
Authors:
|
M Mure; C R Martling; S G Lindahl |
Related Documents
:
|
18378089 - Cardiac dysfunction after burns. 18826859 - Effects of nocturnal oxygen therapy on sleep apnea syndrome in peritoneal dialysis pati... 8914569 - Accuracy of pulse oximetry in pigmented patients. 21585169 - Nephrolithiasis in medullary sponge kidney. 1845929 - Effects of granulocyte-macrophage colony-stimulating factor in burn patients. 11533009 - Effect of serum from different patient populations on the serum bactericidal test. 9849709 - Glucocorticoid receptors on mononuclear leukocytes in polycystic ovary syndrome. 9515839 - Pathologic findings in lung volume reduction surgery. 2413869 - Modulatory effect of sera from scleroderma patients on lymphocyte-induced angiogenesis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Critical care medicine Volume: 25 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1997 Sep |
Date Detail:
|
Created Date: 1997-10-02 Completed Date: 1997-10-02 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1539-44 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adult Aged Female Follow-Up Studies Humans Intensive Care Male Middle Aged Oxygen / blood Oxygen Consumption* Prone Position* Pulmonary Gas Exchange* Respiratory Insufficiency / metabolism*, physiopathology, therapy* Supine Position Survival Analysis Time Factors |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
|
Crit Care Med. 1997 Sep;25(9):1453-4
[PMID:
9295813
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An evaluation of empiric vs. nomogram-based dosing of heparin in an intensive care unit.
Next Document: A comparison of hemodynamic parameters derived from transthoracic electrical bioimpedance with those...