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Dramatic and delayed response to Doxorubicin-dacarbazine chemotherapy of a giant desmoid tumor: case report and literature review.
MedLine Citation:
PMID:  23569447     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Desmoid tumors are benign, slow-growing mesenchymal tumors. Aggressiveness is local with no potential for metastasis or dedifferentiation. The treatment is challenging, particularly in the case of huge intra-abdominal locations. We, herein, report on a 21-year-old patient with a giant intra-abdominal desmoid tumor occupying substantially the entire abdominal cavity. After failure of a first-line combination of celecoxib and tamoxifen, the patient was given doxorubicin-dacarbazine chemotherapy. The treatment was well tolerated, and rapidly, the clinical digestive symptoms improved. After 6 cycles, the computed tomography scan showed a partial response (regression of tumor volume by 55%). During follow-up, the tumor continued to regress: 25 months after the end of chemotherapy, the tumor volume had regressed by 95% when compared to the start of computed tomography and by 90% when compared to the end of chemotherapy. Thirty-three months after the diagnosis, the patient is alive without any symptom. Our case provides further evidence of the remarkable efficacy of a doxorubicin-dacarbazine regimen, especially in function- or life-threatening situations where a rapid response is required. We review the literature and discuss the challenging issue regarding treatment of desmoid tumors.
Authors:
Audrey Monneur; Bruno Chetaille; Delphine Perrot; Jérôme Guiramand; François Bertucci
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Publication Detail:
Type:  Journal Article     Date:  2013-03-05
Journal Detail:
Title:  Case reports in oncology     Volume:  6     ISSN:  1662-6575     ISO Abbreviation:  Case Rep Oncol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-04-10     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  101517601     Medline TA:  Case Rep Oncol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  -    
Affiliation:
Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France.
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