| Dramatic Decline in Prevalence of Helicobacter pylori and Peptic Ulcer Disease in an Endoscopy-referral Population. | |
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MedLine Citation:
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PMID: 21396510 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To determine if endoscopic Helicobacter pylori and peptic ulcer disease prevalence has changed over an 11-year period in a rural region. METHODS: Current endoscopic records were reviewed and compared with similar data obtained over a time period 11 years earlier at the same institution with regard to H. pylori status, endoscopic findings, microscopic pathologic findings, and medication use. RESULTS: There were 251 records reviewed in the current study group (mean age 52.8 years, 59.0% female) and 263 in the previous group (mean age 60.1 years, 56.7% female). H. pylori was positive in 17 (6.8%) in the current study and 173 (65.8%) in the earlier study (P <.0001). Peptic ulcer disease (PUD) was present in 14 (5.6%) in the current study and in 102 (38.8%) in the earlier study (P <.0001). H. pylori was positive in 1 of the 14 PUD patients (7.1%) in the current study and in 78 of 102 (76.5%) in the previous study (P <.0001). CONCLUSIONS: Endoscopic H. pylori prevalence in our rural locality has decreased substantially over the past decade and may reflect local overall prevalence trends, although underestimation is likely due to widespread prior noninvasive H. pylori diagnosis and treatment. Endoscopic PUD also has decreased precipitously, possibly related to changes in regional H. pylori characteristics and prolific use of antisecretory agents. Changing geographic trends regarding acid-peptic disease may prompt modification of diagnostic approach and treatment. |
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Authors:
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Brittain McJunkin; Moussa Sissoko; Joel Levien; Jessica Upchurch; Ali Ahmed |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 124 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
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Languages: eng Pagination: 260-4 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Internal Medicine, West Virginia University Health Sciences Center, Charleston Division, Charleston, WV. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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