Document Detail


Dracorhodin perchlorate induces apoptosis in HL-60 cells.
MedLine Citation:
PMID:  16864444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dracorhodin perchlorate, an anthocyanin red pigment, induces human premyelocytic leukemia HL-60 cell death through apoptotic pathway. Caspase -1, -3, -8, -9, and -10 inhibitors partially reversed the cell death induced by dracorhodin perchlorate. Caspase-3 and -8 were activated followed to the degradation of caspase-3 substrates, inhibitor of caspase-activated DNase (ICAD) and poly-(ADP-ribose) polymerase (PARP). Dracorhodin perchlorate up-regulated the expression ratio of mitochondrial proteins, Bax/Bcl-XL. The cell death was accompanied with phosphorylation of ERK, JNK and p38 MAPK and partially reduced by MEK inhibitor (PD98059), JNK MAPK inhibitor (SP600125) and p38 MAPK inhibitor (SB 203580). Taken together, dracorhodin perchlorate-induced apoptosis in HL-60 cells via up-regulation of Bax, activation of caspases and ERK/p38/JNK MAPKs.
Authors:
M-Y Xia; M-W Wang; Z Cui; S-I Tashiro; S Onodera; M Minami; T Ikejima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  8     ISSN:  1028-6020     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2007-02-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-43     Citation Subset:  IM    
Affiliation:
Shenyang Pharmaceutical University, Department of Pharmacology, Shenyang, 110016, China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  pharmacology*
Apoptosis / drug effects*
Benzopyrans / chemistry,  pharmacology*
Caspases / metabolism
Dose-Response Relationship, Drug
Enzyme Activation
HL-60 Cells
Humans
MAP Kinase Kinase 4 / metabolism
Mitogen-Activated Protein Kinase Kinases / metabolism
Molecular Structure
bcl-2-Associated X Protein / metabolism
p38 Mitogen-Activated Protein Kinases / metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Benzopyrans; 0/bcl-2-Associated X Protein; 643-56-1/dracorhodin; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 2.7.12.2/MAP Kinase Kinase 4; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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