Document Detail

Doxycycline suppression of ischemia-reperfusion-induced hepatic injury.
MedLine Citation:
PMID:  8070903     Owner:  NLM     Status:  MEDLINE    
Leukocytes, in particular polymorphonuclear neutrophils (PMNs), are believed to play a central role in ischemia-reperfusion (I/R)-induced tissue injury. Changes in endothelial cells occurring during ischemia promote PMN binding to these cells during reperfusion, which primers PMN synthesis of oxygen radicals and release of cytotoxic proteins. These events lead to vascular damage and subsequent tissue injury. Recently we have shown that doxycycline (Dc), a member of the tetracycline family of antibiotics, inhibits PMN superoxide (O2) synthesis and degranulation in vitro. It also suppresses PMN-mediated RBC, fibroblast, and endothelial cytotoxicity, properties of the drug that may make it of use to protect tissues from I/R-induced injury. In this study we demonstrate that Dc administration either prior to clamping of the portal circulation, or 1 h after the reperfusion, significantly suppressed liver damage as assessed by serum levels of a marker of hepatic injury, alanine aminotransferase (s-ALT). The reduction in s-ALT was not a result of reduced reflow in the Dc-treated rats as indicated by Evans' blue perfusion data. The findings suggest that Dc and possibly other tetracyclines may be of value in protecting tissues and organs from I/R-mediated damage even if the drug is given after the ischemic event has occurred.
J R Smith; W L Gabler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation     Volume:  18     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-28     Completed Date:  1994-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Department of Biologic Structure and Function and Oral Molecular Biology School of Dentistry, Oregon Health Sciences University, Portland 97201.
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MeSH Terms
Alanine Transaminase / blood
Doxycycline / pharmacology*
Liver / pathology*
Liver Circulation*
Rats, Inbred F344
Rats, Sprague-Dawley
Reperfusion Injury / pathology*
Time Factors
Reg. No./Substance:
564-25-0/Doxycycline; EC Transaminase

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