Document Detail


Doxycycline in autoimmune central nervous system disorders in children: an in vitro study.
MedLine Citation:
PMID:  17990580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tetracyclines have antiinflammatory properties. To test the in vitro effect of doxycycline in autoimmune neurological disorders of childhood, peripheral blood lymphocytes from multiple sclerosis (n=11), acute disseminated encephalomyelitis (n=12), and control patients (epilepsy and headache, n=12), all aged 5-17, were examined for proliferation, migration, and apoptosis after culture with doxycycline, concanavalin A and myelin basic protein for 48 hours. Doxycycline increased proliferation in the control group, and less in the multiple sclerosis group but not in the acute disseminated encephalomyelitis group (p<0.03). It increased apoptosis in multiple sclerosis patients (p<0.02). According to this preliminary study, doxycycline might have immunomodulatory effects in children, justifying future studies with larger and more homogeneous patient groups.
Authors:
Banu Anlar; Nesrin Senbil; Alev Güven
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  49     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2007-11-09     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  274-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Bacterial Agents / pharmacology,  therapeutic use*
Apoptosis / drug effects
Cell Proliferation / drug effects
Child
Doxycycline / pharmacology,  therapeutic use*
Encephalomyelitis, Acute Disseminated / drug therapy*
Enzyme Inhibitors / pharmacology
Female
Humans
Macrolides / pharmacology
Male
Multiple Sclerosis / drug therapy*
Myelin Basic Proteins / pharmacology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Enzyme Inhibitors; 0/Macrolides; 0/Myelin Basic Proteins; 564-25-0/Doxycycline; 80890-47-7/concanamycin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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