Document Detail

Doxorubicin cardiotoxicity in children: reduced incidence of cardiac dysfunction associated with continuous-infusion schedules.
MedLine Citation:
PMID:  11295089     Owner:  NLM     Status:  MEDLINE    
We retrospectively reviewed the medical records of 97 children (59 boys and 38 girls) with a median age of 13 +/- 4 years who had been treated with continuous infusion of doxorubicin at a dosage of 60 mg/m2 over 24 h (61 patients) or at a dosage of 75 mg/m2 over 72 h (36 patients). The drug was administered every 3 weeks. The cardiac status of patients was evaluated as a baseline and every 6 months during, and following therapy (median, 30.5 months). The evaluations included M-mode and two-dimensional echocardiography. Congestive heart failure developed in only one patient in this series, an 8-year-old girl who ultimately died of her cardiac complication. This incidence of doxorubicin-induced cardiotoxicity was compared with that seen in a control group of pediatric patients previously treated with doxorubicin at similar dosages but with a rapid infusion. The result compared favorably to the 13% incidence of cardiotoxicity (p = 0.03) and 7% mortality (p < 0.01) in the control group. No changes in the levels of tumor response were noted in children treated by continuous infusion when compared with historical controls. Continuous-infusion schedules of doxorubicin thus result in fewer incidences of cardiotoxicity in children and should be considered for wider application in pediatric cancer patients receiving doxorubicin.
S G Berrak; M S Ewer; N Jaffe; P Pearson; H Ried; H A Zietz; R S Benjamin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  8     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-04-11     Completed Date:  2001-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  611-4     Citation Subset:  IM    
Departments of Medical Specialties and Melanoma/Sarcoma and the Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Antineoplastic Agents / administration & dosage,  adverse effects*
Child, Preschool
Doxorubicin / administration & dosage,  adverse effects*
Drug Administration Schedule
Heart / drug effects*
Heart Failure / chemically induced,  epidemiology*,  prevention & control
Infusions, Intravenous
Neoplasms / drug therapy
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Antineoplastic Agents; 23214-92-8/Doxorubicin

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