| Doxorubicin cardiotoxicity in children: reduced incidence of cardiac dysfunction associated with continuous-infusion schedules. | |
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MedLine Citation:
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PMID: 11295089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We retrospectively reviewed the medical records of 97 children (59 boys and 38 girls) with a median age of 13 +/- 4 years who had been treated with continuous infusion of doxorubicin at a dosage of 60 mg/m2 over 24 h (61 patients) or at a dosage of 75 mg/m2 over 72 h (36 patients). The drug was administered every 3 weeks. The cardiac status of patients was evaluated as a baseline and every 6 months during, and following therapy (median, 30.5 months). The evaluations included M-mode and two-dimensional echocardiography. Congestive heart failure developed in only one patient in this series, an 8-year-old girl who ultimately died of her cardiac complication. This incidence of doxorubicin-induced cardiotoxicity was compared with that seen in a control group of pediatric patients previously treated with doxorubicin at similar dosages but with a rapid infusion. The result compared favorably to the 13% incidence of cardiotoxicity (p = 0.03) and 7% mortality (p < 0.01) in the control group. No changes in the levels of tumor response were noted in children treated by continuous infusion when compared with historical controls. Continuous-infusion schedules of doxorubicin thus result in fewer incidences of cardiotoxicity in children and should be considered for wider application in pediatric cancer patients receiving doxorubicin. |
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Authors:
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S G Berrak; M S Ewer; N Jaffe; P Pearson; H Ried; H A Zietz; R S Benjamin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Oncology reports Volume: 8 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2001 May-Jun |
Date Detail:
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Created Date: 2001-04-11 Completed Date: 2001-07-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 611-4 Citation Subset: IM |
Affiliation:
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Departments of Medical Specialties and Melanoma/Sarcoma and the Division of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antineoplastic Agents / administration & dosage, adverse effects* Child Child, Preschool Doxorubicin / administration & dosage, adverse effects* Drug Administration Schedule Electrocardiography Female Heart / drug effects* Heart Failure / chemically induced, epidemiology*, prevention & control Humans Incidence Infant Infusions, Intravenous Male Neoplasms / drug therapy Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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