| Doxorubicin-associated delayed ventricular fibrillation in acute promyelocytic leukemia. | |
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MedLine Citation:
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PMID: 6401894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 16-year-old schoolgirl presented with acute promyelocytic leukemia. 10 days after induction chemotherapy with doxorubicin and cytosine arabinoside together with heparinisation for the accompanying disseminated intravascular coagulopathy, she developed ventricular fibrillation. Following successful cardiac resuscitation a gated blood pool scan showed a left ventricular ejection fraction of 49%. Despite this event the patient was subsequently rechallenged with doxorubicin without any adverse cardiac effect. The exact mechanism for this delayed doxorubicin-associated cardiac arrhythmia is not clear, but electrolyte disturbance and heparin-doxorubicin interaction may have played a contributory role. |
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Authors:
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T E Gan; P H Ellims; N Tong; J M Barned; M B Van der Weyden |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta haematologica Volume: 69 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 1983 |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 52-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antibiotics, Antineoplastic / adverse effects*, therapeutic use Doxorubicin / adverse effects*, therapeutic use Female Humans Leukemia, Myeloid, Acute / complications, drug therapy* Time Factors Ventricular Fibrillation / chemically induced*, complications |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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