| Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy. | |
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MedLine Citation:
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PMID: 21218795 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hydrophobically modified maghemite (γ-Fe(2)O(3)) nanoparticles were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(l-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formation method gives simple access to highly magnetic nanoparticles (MNPs) (loaded up to 70 wt %) together with good control over the vesicles size (100-400 nm). The simultaneous loading of maghemite nanoparticles and doxorubicin was also achieved by nanoprecipitation. The deformation of the vesicle membrane under an applied magnetic field has been evidenced by small angle neutron scattering. These superparamagnetic hybrid self-assemblies display enhanced contrast properties that open potential applications for magnetic resonance imaging. They can also be guided in a magnetic field gradient. The feasibility of controlled drug release by radio frequency magnetic hyperthermia was demonstrated in the case of encapsulated doxorubicin molecules, showing the viability of the concept of magneto-chemotherapy. These magnetic polymersomes can be used as efficient multifunctional nanocarriers for combined therapy and imaging. |
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Authors:
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Charles Sanson; Odile Diou; Julie Thévenot; Emmanuel Ibarboure; Alain Soum; Annie Brûlet; Sylvain Miraux; Eric Thiaudière; Sisareuth Tan; Alain Brisson; Vincent Dupuis; Olivier Sandre; Sébastien Lecommandoux |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-10 |
Journal Detail:
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Title: ACS nano Volume: - ISSN: 1936-086X ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101313589 Medline TA: ACS Nano Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Université de Bordeaux/IPB, ENSCBP, 16 avenue Pey Berland, 33607 Pessac Cedex, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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