Document Detail


Doxepin toxicity in a child following topical administration.
MedLine Citation:
PMID:  10917379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe a case of a child with altered mental status following the topical administration of doxepin. CASE SUMMARY: A five-year-old Hispanic girl was brought to the emergency department because she was difficult to arouse at school. She had recently developed a generalized eczematous rash for which she was prescribed doxepin hydrochloride 5% cream. An entire tube (30 g) of doxepin cream was applied in the 24 hours prior to presentation. The patient was responsive only to noxious stimuli, with no focal neurologic abnormalities. She was decontaminated and observed in a pediatric intensive care unit. By 18 hours after presentation, she had fully recovered and was discharged. CONCLUSIONS: Topical doxepin, available as a 5% cream, is indicated for the treatment of pruritus secondary to eczematous dermatoses in adults. Diminished skin integrity and the application of a massive quantity of doxepin 5% cream to a large body surface area contributed to the toxicity in this child. Since the safety and efficacy of doxepin cream has not been established in children younger than 12 years, it should be used with caution in this population.
Authors:
M Zell-Kanter; T S Toerne; K Spiegel; A Negrusz
Related Documents :
10593549 - Neurodevelopmental outcome in children with intrauterine growth retardation: a 3-year f...
461599 - Development of psychosexual concepts in relation to expressive language performance.
3428079 - Evaluation of pattern visual evoked cortical potentials for prescribing spectacles in m...
11048739 - Inborn errors of metabolism discovered in asian department of pediatrics and mental ret...
443279 - Correlates of social competence in retarded children.
868929 - Communication style and effectiveness in homogeneous and heterogeneous dyads of retarde...
24334229 - Toddlers with delayed expressive language: an overview of the characteristics, risk fac...
20532679 - Use of pyridoxine and pyridostigmine in children with vincristine-induced neuropathy.
19665349 - Characteristics and professional use of voice in street children in aracaju, brazil.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  34     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-11-30     Completed Date:  2000-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  328-9     Citation Subset:  IM    
Affiliation:
Toxikon Consortium, Division of Occupational Medicine, Cook County Hospital, Chicago, IL 60612, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Antipruritics / administration & dosage,  adverse effects*,  therapeutic use
Child, Preschool
Doxepin / administration & dosage,  adverse effects*,  therapeutic use
Eczema / drug therapy
Female
Humans
Sleep Stages / drug effects*
Chemical
Reg. No./Substance:
0/Antipruritics; 1668-19-5/Doxepin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Warfarin and celecoxib interaction.
Next Document:  Severe thrombocytopenia associated with alatrofloxacin.