Document Detail

Doxepin toxicity in a child following topical administration.
MedLine Citation:
PMID:  10917379     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe a case of a child with altered mental status following the topical administration of doxepin. CASE SUMMARY: A five-year-old Hispanic girl was brought to the emergency department because she was difficult to arouse at school. She had recently developed a generalized eczematous rash for which she was prescribed doxepin hydrochloride 5% cream. An entire tube (30 g) of doxepin cream was applied in the 24 hours prior to presentation. The patient was responsive only to noxious stimuli, with no focal neurologic abnormalities. She was decontaminated and observed in a pediatric intensive care unit. By 18 hours after presentation, she had fully recovered and was discharged. CONCLUSIONS: Topical doxepin, available as a 5% cream, is indicated for the treatment of pruritus secondary to eczematous dermatoses in adults. Diminished skin integrity and the application of a massive quantity of doxepin 5% cream to a large body surface area contributed to the toxicity in this child. Since the safety and efficacy of doxepin cream has not been established in children younger than 12 years, it should be used with caution in this population.
M Zell-Kanter; T S Toerne; K Spiegel; A Negrusz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  34     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-11-30     Completed Date:  2000-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  328-9     Citation Subset:  IM    
Toxikon Consortium, Division of Occupational Medicine, Cook County Hospital, Chicago, IL 60612, USA.
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MeSH Terms
Administration, Topical
Antipruritics / administration & dosage,  adverse effects*,  therapeutic use
Child, Preschool
Doxepin / administration & dosage,  adverse effects*,  therapeutic use
Eczema / drug therapy
Sleep Stages / drug effects*
Reg. No./Substance:
0/Antipruritics; 1668-19-5/Doxepin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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