| Doxazosin: a new approach to hypertension and benign prostatic hyperplasia. | |
| | |
MedLine Citation:
|
PMID: 8733335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Doxazosin, a selective alpha 1-adrenoceptor antagonist, is an established first-line antihypertensive agent that is being introduced for the management of benign prostatic hyperplasia. Hypertension and benign prostatic hyperplasia are linked by the sympathetic nervous system, which has an aetiologic role in both conditions. The alpha 1-adrenoceptor is a mediator of increased tension, both in vascular and prostatic smooth muscle. Studies have shown that doxazosin, through its balanced action on alpha 1-adrenoceptor subtypes, reduces blood pressure and improves other risk factors for coronary heart disease, such as lipid profile, insulin sensitivity, left ventricular hypertrophy, platelet aggregation and fibrinolysis. Data are now accumulating to show that doxazosin improves urinary flow rates and symptoms in patients with benign prostatic hyperplasia. These effects have been demonstrated in controlled clinical studies, within weeks, and long term. Since hypertension and benign prostatic hyperplasia are widespread and often undiagnosed in the community, particularly with increasing age, doxazosin may be a particularly appropriate therapy for the considerable number of older men with both conditions. |
| | |
Authors:
|
J L Pool |
Related Documents
:
|
3201655 - Bladder replacement after radical cystectomy using detubularized right colonic segment. 3564215 - High pressure pyelocalyceal reflux. case presentation. 11451005 - Pharmacological effect of amezinium on urethra and bladder of rabbits. 1383575 - Impact of radical prostatectomy on the characteristics of bladder and urethra. 17042905 - Early recovery from post-traumatic acute respiratory distress syndrome. 235795 - Heart transplantation in endotoxin shock. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The British journal of clinical practice Volume: 50 ISSN: 0007-0947 ISO Abbreviation: Br J Clin Pract Publication Date: 1996 Apr-May |
Date Detail:
|
Created Date: 1996-10-03 Completed Date: 1996-10-03 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372546 Medline TA: Br J Clin Pract Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 154-63 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-Antagonists
/
therapeutic use* Aged Antihypertensive Agents / therapeutic use* Clinical Trials as Topic Doxazosin / therapeutic use* Humans Male Prostatic Hyperplasia / drug therapy* Sympatholytics / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Antagonists; 0/Antihypertensive Agents; 0/Sympatholytics; 74191-85-8/Doxazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Domiciliary oxygen.
Next Document: Changing incidence of atrial fibrillation following coronary artery bypass grafting: a retrospective...