Document Detail

Doxazosin for the management of distal-ureteral stones.
MedLine Citation:
PMID:  17523910     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy of doxazosin in inducing spontaneous passage of stones in the distal ureter and to compare its efficacy according to the size of the stone. PATIENTS AND METHODS: Seventy-three patients with a mean age of 46.38 +/- 10.17 years who presented with a distal-ureteral stone were divided into four groups according to stone size and drug treatment: <5 mm without doxazosin (group A; n=15); 5-10 mm (group B; n=16); <5 mm with doxazosin 4 mg/day for 4 weeks (group C; n=20); and 5-10 mm with doxazosin 4 mg/day for 4 weeks (group D; n=22). Groups A and B served as controls for groups C and D, respectively. RESULTS: Spontaneous stone passage was documented in 9 patients (60%) in group A v 17 (85%) in group C (P=0.047) and 7 (43.75%) in group B v 16 (72.73%) in group D (P=0.036). The average expulsion time was 8.78 +/- 1.09 days in group A v 7.59 +/- 0.80 days in group C (P=0.004) and 12.14 +/- 1.35 days in group B v 7.06 +/- 1.29 days in group D (P<0.0001). The number of pain episodes in group D patients was significantly lower than in group B (P +/- 0.0078). CONCLUSIONS: Doxazosin treatment proved to be safe and effective for distal-ureteral stones, as determined by earlier expulsion, decreased colic frequency, and absence of side effects. The efficacy of doxazosin was significantly higher for 5-to 10-mm stones than for smaller ones.
E N Liatsikos; P F Katsakiori; K Assimakopoulos; T Voudoukis; P Kallidonis; C Constantinides; A Athanasopoulos; Jens-Uwe Stolzenburg; P Perimenis
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  21     ISSN:  0892-7790     ISO Abbreviation:  J. Endourol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-25     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  538-41     Citation Subset:  IM    
Department of Urology, University of Patras, School of Medicine, Patras, Greece.
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MeSH Terms
Adrenergic alpha-Antagonists / administration & dosage*
Colic / drug therapy,  pathology
Doxazosin / administration & dosage*
Middle Aged
Models, Statistical
Sample Size
Treatment Outcome
Ureteral Calculi / drug therapy*,  pathology*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 74191-85-8/Doxazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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