| Doxazosin for the management of distal-ureteral stones. | |
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MedLine Citation:
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PMID: 17523910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy of doxazosin in inducing spontaneous passage of stones in the distal ureter and to compare its efficacy according to the size of the stone. PATIENTS AND METHODS: Seventy-three patients with a mean age of 46.38 +/- 10.17 years who presented with a distal-ureteral stone were divided into four groups according to stone size and drug treatment: <5 mm without doxazosin (group A; n=15); 5-10 mm (group B; n=16); <5 mm with doxazosin 4 mg/day for 4 weeks (group C; n=20); and 5-10 mm with doxazosin 4 mg/day for 4 weeks (group D; n=22). Groups A and B served as controls for groups C and D, respectively. RESULTS: Spontaneous stone passage was documented in 9 patients (60%) in group A v 17 (85%) in group C (P=0.047) and 7 (43.75%) in group B v 16 (72.73%) in group D (P=0.036). The average expulsion time was 8.78 +/- 1.09 days in group A v 7.59 +/- 0.80 days in group C (P=0.004) and 12.14 +/- 1.35 days in group B v 7.06 +/- 1.29 days in group D (P<0.0001). The number of pain episodes in group D patients was significantly lower than in group B (P +/- 0.0078). CONCLUSIONS: Doxazosin treatment proved to be safe and effective for distal-ureteral stones, as determined by earlier expulsion, decreased colic frequency, and absence of side effects. The efficacy of doxazosin was significantly higher for 5-to 10-mm stones than for smaller ones. |
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Authors:
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E N Liatsikos; P F Katsakiori; K Assimakopoulos; T Voudoukis; P Kallidonis; C Constantinides; A Athanasopoulos; Jens-Uwe Stolzenburg; P Perimenis |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of endourology / Endourological Society Volume: 21 ISSN: 0892-7790 ISO Abbreviation: J. Endourol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-25 Completed Date: 2007-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807503 Medline TA: J Endourol Country: United States |
Other Details:
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Languages: eng Pagination: 538-41 Citation Subset: IM |
Affiliation:
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Department of Urology, University of Patras, School of Medicine, Patras, Greece. Liatsikos@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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administration & dosage* Adult Colic / drug therapy, pathology Doxazosin / administration & dosage* Female Humans Male Middle Aged Models, Statistical Sample Size Treatment Outcome Ureteral Calculi / drug therapy*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 74191-85-8/Doxazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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