Document Detail


Doxapram on blunted respiratory chemosensitivity to hypoxia in hypoxemic, chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  3626158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated a possible effect of doxapram (a respiratory stimulant) on the peripheral chemoreceptors in man (8 control subjects, 11 bronchitics, and 4 emphysematous). In addition, we determined whether infusion of doxapram could augment blunted chemosensitivity to hypoxia or hypercapnia seen in both chronic obstructive pulmonary disease (COPD) patients and normal subjects. Doxapram infusion caused a significant increase in delta VE/delta SaO2 (p less than 0.05), as well as delta Po.1/delta SaO2 (p less than 0.05) in control subjects, although the changes in both delta VE/delta PeAco2 (where, PeAco2 = end-tidal Pco2) and delta Po.1/delta PeAco2 did not attain significant level. Control subjects with low baseline delta Po.1/delta SaO2 showed significantly larger changes in both delta Po.1/delta SaO2 and delta VE/SaO2 during doxapram infusion than the patients with chronic bronchitis (0.02 less than p less than 0.05). We conclude that doxapram increases chemosensitivity to hypoxia and slightly increase chemosensitivity to hypercapnia, indicating its primary action being stimulation of peripheral chemoreceptors, and doxapram stimulates chemoreceptors little in patients with chronic bronchitis, whereas blunted hypoxic response in normal subjects could be increased markedly.
Authors:
T Yoshikawa; H Yamamoto; M Nishimura; Y Kawakami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of medicine     Volume:  26     ISSN:  0021-5120     ISO Abbreviation:  Jpn. J. Med.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-10-20     Completed Date:  1987-10-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0247713     Medline TA:  Jpn J Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  194-202     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anoxia / physiopathology
Bronchitis / physiopathology
Chemoreceptor Cells / drug effects*
Doxapram / administration & dosage,  pharmacology*
Female
Forced Expiratory Flow Rates
Humans
Hypercapnia / physiopathology
Infusions, Intravenous
Lung Diseases, Obstructive / physiopathology*
Male
Middle Aged
Respiration / drug effects*
Vital Capacity / drug effects
Chemical
Reg. No./Substance:
309-29-5/Doxapram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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