Document Detail

Doxacurium pharmacodynamics in children during volatile and opioid-based anaesthesia.
MedLine Citation:
PMID:  8686826     Owner:  NLM     Status:  MEDLINE    
The interaction between doxacurium and halothane, isoflurane or alfentanil has not been studied in children. Using the cumulative dose-response technique and electromyography, we determined ED50 and ED90 of doxacurium during halothane (n = 9), isoflurane (n = 12) or alfentanil (n = 9) based anaesthesia in children aged 2-10 years. Both isoflurane and halothane potentiated the effects of doxacurium compared to alfentanil. The ED50 for doxacurium/halothane was 23.9 compared to 32.7 for doxacurium/alfentanil. The ED90 for doxacurium/isoflurane was 32.7 compared to 48.2 doxacurium/alfentanil (p < 0.05). There were no significant time course differences between the groups. When equipotent doses of doxacurium were used to provide muscle relaxation the duration of the neuromuscular block was similar in children who received aflentanil, halothane or isoflurane supplementation of N2O/O2 anaesthesia.
C Kern; E Tassonyi; J C Rouge; O H Wilder-Smith; J F Pittet
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  51     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-08-19     Completed Date:  1996-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  361-4     Citation Subset:  AIM; IM    
Department of Anaesthesiology, Geneva University Hospital, Switzerland.
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MeSH Terms
Anesthetics, Inhalation*
Anesthetics, Intravenous*
Child, Preschool
Dose-Response Relationship, Drug
Drug Interactions
Isoquinolines* / pharmacokinetics
Neuromuscular Junction / drug effects*
Neuromuscular Nondepolarizing Agents* / pharmacokinetics
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Isoquinolines; 0/Neuromuscular Nondepolarizing Agents; 106819-53-8/doxacurium; 151-67-7/Halothane; 26675-46-7/Isoflurane; 71195-58-9/Alfentanil

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