| Downstream targets of Nm23-H1: gene expression profiling of CAL 27 cells using DNA microarray. | |
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MedLine Citation:
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PMID: 16739125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23 plays a key role in different cellular processes. The role of nm23-H1 in these processes still has to be elucidated. Our goal was to identify Nm23-H1 downstream targets by subjecting Nm23-H1 overexpressing CAL 27 cells oral squamous cell carcinoma (OSSC) to microarray analysis. The genes with changed expression patterns could be clustered into several groups: transforming growth factor beta (TGFbeta) signaling pathway, cell adhesion, invasion and motility, proteasome machinery, cell-cycle, epithelial structural and related molecules and others. Based on the expression patterns observed we presume that nm23-H1 might have a role in OSSCs, which should be confirmed by future experiments. |
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Authors:
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Maja Herak Bosnar; Ruzica Bago; Koraljka Gall-Troselj; Thomas Streichert; Jasminka Pavelić |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular carcinogenesis Volume: 45 ISSN: 0899-1987 ISO Abbreviation: Mol. Carcinog. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-24 Completed Date: 2006-09-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8811105 Medline TA: Mol Carcinog Country: United States |
Other Details:
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Languages: eng Pagination: 627-33 Citation Subset: IM |
Affiliation:
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Division of Molecular Medicine, Rudjer Bosković Institute, Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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genetics* Gene Expression Profiling* Gene Expression Regulation, Neoplastic* Genes, Neoplasm* Humans Mouth Neoplasms / genetics* NM23 Nucleoside Diphosphate Kinases Nucleoside-Diphosphate Kinase / genetics, physiology* Oligonucleotide Array Sequence Analysis |
| Chemical | |
Reg. No./Substance:
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0/NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6/NME1 protein, human; EC 2.7.4.6/Nucleoside-Diphosphate Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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