Document Detail

Downstream targets of Nm23-H1: gene expression profiling of CAL 27 cells using DNA microarray.
MedLine Citation:
PMID:  16739125     Owner:  NLM     Status:  MEDLINE    
The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23 plays a key role in different cellular processes. The role of nm23-H1 in these processes still has to be elucidated. Our goal was to identify Nm23-H1 downstream targets by subjecting Nm23-H1 overexpressing CAL 27 cells oral squamous cell carcinoma (OSSC) to microarray analysis. The genes with changed expression patterns could be clustered into several groups: transforming growth factor beta (TGFbeta) signaling pathway, cell adhesion, invasion and motility, proteasome machinery, cell-cycle, epithelial structural and related molecules and others. Based on the expression patterns observed we presume that nm23-H1 might have a role in OSSCs, which should be confirmed by future experiments.
Maja Herak Bosnar; Ruzica Bago; Koraljka Gall-Troselj; Thomas Streichert; Jasminka Pavelić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular carcinogenesis     Volume:  45     ISSN:  0899-1987     ISO Abbreviation:  Mol. Carcinog.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-24     Completed Date:  2006-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811105     Medline TA:  Mol Carcinog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-33     Citation Subset:  IM    
Division of Molecular Medicine, Rudjer Bosković Institute, Zagreb, Croatia.
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MeSH Terms
Carcinoma, Squamous Cell / genetics*
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic*
Genes, Neoplasm*
Mouth Neoplasms / genetics*
NM23 Nucleoside Diphosphate Kinases
Nucleoside-Diphosphate Kinase / genetics,  physiology*
Oligonucleotide Array Sequence Analysis
Reg. No./Substance:
0/NM23 Nucleoside Diphosphate Kinases; EC protein, human; EC Kinase

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