Document Detail

Downstaging of hepatocellular carcinoma prior to liver transplant: is there a role for adjuvant sorafenib in locoregional therapy?
MedLine Citation:
PMID:  20443078     Owner:  NLM     Status:  MEDLINE    
Hepatocellular carcinoma (HCC) remains a common cause of mortality worldwide. Liver transplantation has emerged as the optimal treatment for cirrhotic patients with HCC; however, the shortage of donor organs leaves waitlisted patients at risk for disease progression beyond transplant criteria. Prevention of waitlist dropout has fueled investigation into a wide array of locoregional therapies for the management of HCC in candidates awaiting liver transplantation. We present a patient with HCC who underwent treatment with sorafenib, which resulted in a remarkable reduction in tumor burden to allow for liver transplant listing.
Parsia A Vagefi; Ryutaro Hirose
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of gastrointestinal cancer     Volume:  41     ISSN:  1941-6636     ISO Abbreviation:  J Gastrointest Cancer     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-02-17     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101479627     Medline TA:  J Gastrointest Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Division of Transplantation, University of California, San Francisco, CA 94143, USA.
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MeSH Terms
Antineoplastic Agents / therapeutic use
Benzenesulfonates / therapeutic use*
Carcinoma, Hepatocellular / pathology,  therapy*,  virology
Hepatitis C, Chronic / complications,  physiopathology,  surgery
Liver Cirrhosis / etiology,  physiopathology,  surgery
Liver Neoplasms / pathology,  therapy*,  virology
Liver Transplantation*
Middle Aged
Neoadjuvant Therapy / methods*
Pyridines / therapeutic use*
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Antineoplastic Agents; 0/Benzenesulfonates; 0/Pyridines; 0/alpha-Fetoproteins; 0/sorafenib

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