| Down's syndrome. | |
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MedLine Citation:
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PMID: 12699967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sequencing of chromosome 21 and the use of models of Down's syndrome in mice have allowed us to relate genes and sets of genes to the neuropathogenesis of this syndrome, and to better understand its phenotype. Research in prenatal screening and diagnosis aims to find methods to identify fetuses with Down's syndrome, and reduce or eliminate the need for amniocentesis. Other areas of active research and clinical interest include the association of Down's syndrome with coeliac disease and Alzheimer's disease, and improved median age of death. Medical management of the syndrome requires an organised approach of assessment, monitoring, prevention, and vigilance. Improvements in quality of life of individuals with Down's syndrome have resulted from improvements in medical care, identification and treatment of psychiatric disorders (such as depression, disruptive behaviour disorders, and autism), and early educational interventions with support in typical educational settings. Approaches and outcomes differ throughout the world. |
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Authors:
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Nancy J Roizen; David Patterson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Lancet Volume: 361 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-17 Completed Date: 2003-05-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 1281-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA. roizenn@upstate.edu <roizenn@upstate.edu> |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Down Syndrome* / complications, diagnosis, genetics Female Genetic Testing Humans Infant, Newborn Life Expectancy Male Mental Disorders / etiology Pregnancy Prenatal Diagnosis |
| Comments/Corrections | |
Comment In:
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Lancet. 2003 Jul 5;362(9377):80-1
[PMID:
12853215
]
Lancet. 2003 Jul 5;362(9377):81 [PMID: 12853216 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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