Document Detail

Down's syndrome: occurrence of ALZ-50 reactive neurons and the formation of senile plaques.
MedLine Citation:
PMID:  1387679     Owner:  NLM     Status:  MEDLINE    
We have histopathologically investigated the hippocampal formation in 4 individuals with Down's syndrome (DS), 7 control individuals, and 3 individuals dying after being in coma 3-7 days. Adjacent sections of brain were stained by the Bielschowsky method and by ALZ-50 immunocytochemical methods. ALZ-50 immunoreactive neurons were found in each individual with DS and only in the control infants. Neither ALZ-50-immunoreactive features nor abnormal silver-positive features stained by the Bielschowsky method were found in the adolescent or young adult controls or coma patients. Diffuse form senile plaques (SP) were found only in the oldest DS individual. The data suggest that ALZ-50 reactive neurons persist during the life of an individual with DS and may precede the formation of SP.
D L Sparks; J C Hunsaker
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  109     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-10-06     Completed Date:  1992-10-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Alzheimer's Disease Research Center/Sanders-Brown Center on Aging, Lexington, KY 40536-0230.
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MeSH Terms
Age Factors
Amyloid / analysis*
Antigens / analysis*
Child, Preschool
Coma / complications,  metabolism,  pathology
Down Syndrome / complications,  metabolism,  pathology*
Heart Defects, Congenital / embryology,  genetics
Hippocampus / chemistry,  pathology*
Nerve Tissue Proteins / analysis*
Neurons / chemistry
Grant Support
1-P50-AG05144/AG/NIA NIH HHS; 1-PO1-AG05119/AG/NIA NIH HHS
Reg. No./Substance:
0/Alzheimer's disease antigen; 0/Amyloid; 0/Antigens; 0/Nerve Tissue Proteins

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