Document Detail

Down's syndrome and myocardial reperfusion injury.
MedLine Citation:
PMID:  23960629     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Down syndrome is known to be an independent risk factor for mortality after surgical repair of congenital heart anomalies. It is also associated with neurodegenerative disease and accelerated aging. The mechanism of the latter features has been attributed to abnormal handling of oxygen-free radicals as well as mitochondrial dysfunction. These properties also place the child with Down syndrome at a risk of an exaggerated myocardial ischemia/reperfusion injury. A 6 month old child with Down syndrome is reported who suffered from obvious clinical ischemia/reperfusion injury following an uncomplicated repair of complete AV canal. Both intraoperative as well as postoperative echocardiography documented a satisfactory technical repair. After resting the heart on ECMO the child's myocardial function returned to normal. The mechanisms by which patients with Down syndrome are at risk of ischemia/reperfusion injury are reviewed. Future studies should focus on specific approaches for myocardial protection in the child with Down syndrome undergoing cardiac surgery.
Susheel Kumar; Richard Jonas
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Publication Detail:
Type:  Journal Article     Date:  2010-09-09
Journal Detail:
Title:  Journal of the Saudi Heart Association     Volume:  23     ISSN:  1016-7315     ISO Abbreviation:  J Saudi Heart Assoc     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2013-08-20     Completed Date:  2013-08-20     Revised Date:  2013-08-28    
Medline Journal Info:
Nlm Unique ID:  9887261     Medline TA:  J Saudi Heart Assoc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  -    
Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, United States.
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