Document Detail

Down's syndrome: current screening techniques.
MedLine Citation:
PMID:  2480649     Owner:  NLM     Status:  MEDLINE    
Antenatal screening for Down's syndrome traditionally relied upon performing amniocentesis for karyotype on pregnant women aged 35 years and older. This method detects approximately 20% of all Down's syndrome pregnancies, with a false-positive rate of 4.3%. By incorporating maternal serum alpha-fetoprotein values as an additional screening parameter to maternal age, 28% of all Down's syndrome pregnancies may be diagnosed, with a 35% reduction in false-positive results. Other screening parameters such as maternal serum unconjugated estriol and human chorionic gonadotropin may eventually make it possible to detect more than 65% of pregnancies with chromosomally abnormal fetuses, without compromise in false-positive rates.
R S White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  82     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-23     Completed Date:  1990-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1483-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, George Washington University Medical Center, Washington, DC.
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MeSH Terms
Down Syndrome / blood,  diagnosis*
False Positive Reactions
Fetal Diseases / blood,  diagnosis*
Maternal Age*
Prenatal Diagnosis / methods*,  standards
Reagent Kits, Diagnostic / standards*
Risk Factors
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Reagent Kits, Diagnostic; 0/alpha-Fetoproteins

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