Document Detail

Down's syndrome births and pregnancy terminations in 1989 to 1993: preliminary findings.
MedLine Citation:
PMID:  7632634     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate changes in the numbers of Down's syndrome births and terminations of pregnancies from 1989 to 1993. DESIGN: Data from a national register of cytogenetic diagnoses of karyotypes associated with Down's syndrome were analysed to obtain observed numbers of births and terminations of pregnancies known to be affected. Allowance was made for those cases diagnosed prenatally for whom the eventual outcome of the pregnancies had not yet been ascertained. RESULTS: There has been an increase over the study years in the number of cytogenetic diagnoses of Down's syndrome from 1063 in 1989 to 1137 in 1993, despite an overall fall in births in England and Wales. This is largely due to the increase in antenatal screening and diagnosis, but in part also due to the rise in numbers of pregnancies at increased maternal ages. The rise in prenatally diagnosed cases, of which 92% end in termination, has been accompanied by a fall in both the estimated numbers of affected live births, from 764 in 1989 to 615 in 1993, and the rate per 1000 total live births in the same years from 1.1 to 0.9. CONCLUSIONS: Better and speedier information on the outcome of prenatally diagnosed cases of congenital anomalies such as Down's syndrome would improve the quality of information available for those auditing genetic services or those planning for the care of survivors.
E Alberman; D Mutton; R Ide; A Nicholson; M Bobrow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  102     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-09-12     Completed Date:  1995-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  445-7     Citation Subset:  AIM; IM    
Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Medical College of St. Bartholomew's Hospital, London.
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MeSH Terms
Abortion, Legal / statistics & numerical data*
Down Syndrome / diagnosis,  epidemiology*
England / epidemiology
Pregnancy Outcome
Prenatal Diagnosis
Wales / epidemiology
Comment In:
Br J Obstet Gynaecol. 1995 Jun;102(6):434-5   [PMID:  7632630 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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