| Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses. | |
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MedLine Citation:
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PMID: 16960656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The heterogeneous nuclear ribonucleoprotein C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation through post-transcriptional regulations of certain mRNA species. We studied its role in stress response using siRNA mediated knockdown approach in HeLa cells. Upon transient transfection with plasmid encoding siRNA, the cells showed increased sensitivities to various chemical agents, namely H(2)O(2, )paraquat, camptothecin, ICRF-193 and halogenated deoxyuridines. These results demonstrate that hnRNP C1/C2 is involved in maintenance of cellular homeostasis besides cellular differentiation and proliferation. |
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Authors:
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Mohammad Nazir Hossain; Michihiko Fuji; Kensuke Miki; Morio Endoh; Dai Ayusawa |
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Publication Detail:
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Type: Journal Article Date: 2006-09-08 |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 296 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-03-05 Completed Date: 2007-07-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 151-7 Citation Subset: IM |
Affiliation:
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Kihara Institute for Biological research, Yokohama City University, Maioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antimetabolites
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metabolism Antineoplastic Agents / metabolism Bromodeoxyuridine / metabolism Camptothecin / metabolism Enzyme Inhibitors / metabolism Gene Expression Regulation* Hela Cells Herbicides / metabolism Heterogeneous-Nuclear Ribonucleoprotein Group C / genetics, metabolism* Humans Hydrogen Peroxide / metabolism Oxidants / metabolism Paraquat / metabolism Piperazines / metabolism RNA, Small Interfering / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 0/Antineoplastic Agents; 0/Enzyme Inhibitors; 0/Herbicides; 0/Heterogeneous-Nuclear Ribonucleoprotein Group C; 0/Oxidants; 0/Piperazines; 0/RNA, Small Interfering; 21416-68-2/ICRF 193; 4685-14-7/Paraquat; 59-14-3/Bromodeoxyuridine; 7689-03-4/Camptothecin; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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