Document Detail

Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses.
MedLine Citation:
PMID:  16960656     Owner:  NLM     Status:  MEDLINE    
The heterogeneous nuclear ribonucleoprotein C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation through post-transcriptional regulations of certain mRNA species. We studied its role in stress response using siRNA mediated knockdown approach in HeLa cells. Upon transient transfection with plasmid encoding siRNA, the cells showed increased sensitivities to various chemical agents, namely H(2)O(2, )paraquat, camptothecin, ICRF-193 and halogenated deoxyuridines. These results demonstrate that hnRNP C1/C2 is involved in maintenance of cellular homeostasis besides cellular differentiation and proliferation.
Mohammad Nazir Hossain; Michihiko Fuji; Kensuke Miki; Morio Endoh; Dai Ayusawa
Related Documents :
4306196 - Differential inhibition of attachment and eclipse activities of hela cells for enterovi...
18986216 - Iodine-131 induces mitotic catastrophes and activates apoptotic pathways in hela hep2 c...
15078926 - The human membrane cofactor cd46 is a receptor for species b adenovirus serotype 3.
19087356 - Silencing cytokeratin 18 gene inhibits intracellular replication of trypanosoma cruzi i...
23408356 - Optimization of gene transfection in murine myeloma cell lines using different transfec...
8918946 - Effect of multiplicity of infection on listeria monocytogenes pathogenicity for hela an...
Publication Detail:
Type:  Journal Article     Date:  2006-09-08
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  296     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Kihara Institute for Biological research, Yokohama City University, Maioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antimetabolites / metabolism
Antineoplastic Agents / metabolism
Bromodeoxyuridine / metabolism
Camptothecin / metabolism
Enzyme Inhibitors / metabolism
Gene Expression Regulation*
Hela Cells
Herbicides / metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group C / genetics,  metabolism*
Hydrogen Peroxide / metabolism
Oxidants / metabolism
Paraquat / metabolism
Piperazines / metabolism
RNA, Small Interfering / genetics,  metabolism*
Reg. No./Substance:
0/Antimetabolites; 0/Antineoplastic Agents; 0/Enzyme Inhibitors; 0/Herbicides; 0/Heterogeneous-Nuclear Ribonucleoprotein Group C; 0/Oxidants; 0/Piperazines; 0/RNA, Small Interfering; 21416-68-2/ICRF 193; 4685-14-7/Paraquat; 59-14-3/Bromodeoxyuridine; 7689-03-4/Camptothecin; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Epidemiologic and clinical updates on impulse control disorders: a critical review.
Next Document:  Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insu...