Document Detail


Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses.
MedLine Citation:
PMID:  16960656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heterogeneous nuclear ribonucleoprotein C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation through post-transcriptional regulations of certain mRNA species. We studied its role in stress response using siRNA mediated knockdown approach in HeLa cells. Upon transient transfection with plasmid encoding siRNA, the cells showed increased sensitivities to various chemical agents, namely H(2)O(2, )paraquat, camptothecin, ICRF-193 and halogenated deoxyuridines. These results demonstrate that hnRNP C1/C2 is involved in maintenance of cellular homeostasis besides cellular differentiation and proliferation.
Authors:
Mohammad Nazir Hossain; Michihiko Fuji; Kensuke Miki; Morio Endoh; Dai Ayusawa
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Publication Detail:
Type:  Journal Article     Date:  2006-09-08
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  296     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Affiliation:
Kihara Institute for Biological research, Yokohama City University, Maioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antimetabolites / metabolism
Antineoplastic Agents / metabolism
Bromodeoxyuridine / metabolism
Camptothecin / metabolism
Enzyme Inhibitors / metabolism
Gene Expression Regulation*
Hela Cells
Herbicides / metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group C / genetics,  metabolism*
Humans
Hydrogen Peroxide / metabolism
Oxidants / metabolism
Paraquat / metabolism
Piperazines / metabolism
RNA, Small Interfering / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Antimetabolites; 0/Antineoplastic Agents; 0/Enzyme Inhibitors; 0/Herbicides; 0/Heterogeneous-Nuclear Ribonucleoprotein Group C; 0/Oxidants; 0/Piperazines; 0/RNA, Small Interfering; 21416-68-2/ICRF 193; 4685-14-7/Paraquat; 59-14-3/Bromodeoxyuridine; 7689-03-4/Camptothecin; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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