| Downregulation of the circadian rhythm related gene Arntl2 suppresses diabetes protection in Idd6 NOD.C3H congenic mice. | |
| | |
MedLine Citation:
|
PMID: 20880188 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
1. Our previous studies of the murine genetic locus Idd6 revealed the aryl hydrocarbon receptor nuclear translocator-like protein 2 (Arntl2) as a candidate gene for type 1 diabetes; and in Idd6 NOD.C3H congenic mice, Arntl2 upregulation is linked to decreased diabetes development. 2. In the present study, shRNA plasmids capable of suppressing Arntl2 expression were developed and given to diabetes resistant NOD.C3H congenic mice by hydrodynamic tail vein injection. The effects of Arntl2 suppression on diabetes incidence and immune cell numbers were investigated. 3. Diabetes incidence was increased by Arntl2 mRNA interference in the congenic strain and this was associated with an increase in CD4(+) T cells and a decrease in regulatory T cells in the peripheral immune system. 4. These results provide additional support for the protective role of the Arntl2 gene located in locus Idd6 in diabetes progression in NOD.C3H congenic mice. |
| | |
Authors:
|
Chen-Xia He; Philip Avner; Christian Boitard; Ute Christine Rogner |
Related Documents
:
|
8607798 - Rat adipose ob mrna levels in states of altered circulating glucose and insulin. 19919578 - Differences in mouse models of diabetes mellitus in studies of male reproduction. 6638948 - Metabolism of glucose in the small intestine of lean and obese (ob/ob) mice. 22120488 - Dyslipidaemia among nigerian oil workers with type 2 diabetes mellitus. 15815568 - Education and telephone case management for children with type 1 diabetes: a randomized... 8750208 - Yolk sac concentration of prostaglandin e2 in diabetic pregnancy: further clues to the ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental pharmacology & physiology Volume: 37 ISSN: 1440-1681 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
|
Languages: eng Pagination: 1154-8 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Institut Pasteur, Unité de Génétique Moléculaire Murine, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stel...
Next Document: Abnormal cardiac repolarization in anabolic androgenic steroid users carrying out submaximal exercis...