| Downregulation of T helper cell type 3 in patients with acute coronary syndrome. | |
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MedLine Citation:
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PMID: 19608018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: There is an imbalance between Th1 and Th2 in the development and progression of atherosclerosis and in patients with acute coronary syndrome (ACS) including acute myocardial infarction (AMI) and unstable angina. T helper cell type 3 (Th3), which primarily secretes transforming growth factor beta-1 (TGF-beta1), has been shown to inhibit both Th1 and Th2 cells. The present study was designed to investigate whether Th3 cells are involved in plaque destabilization and the onset of ACS. METHODS: Ninety one patients who underwent diagnostic catheterization were classified into four groups (AMI group, unstable angina group, stable angina group and chest pain syndrome group). The cell frequencies of Th1, Th2 and Th3 were detected using flow cytometry, and the concentrations of their related cytokines IFN-gamma, IL-4 and TGF-beta1 were studied by ELISA. RESULTS: Apart from the imbalance between Th1 and Th2, results revealed a significant decrease in peripheral Th3 number and levels of TGF-beta1 in patients with ACS as compared with those in patients with stable angina and chest pain syndrome (p<0.01). CONCLUSIONS: Downregulation of Th3 cells in patients with ACS may play a potential role in plaque destabilization and the onset of ACS. |
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Authors:
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Qing-wei Ji; Min Guo; Jin-song Zheng; Xiao-bo Mao; Yu-dong Peng; Song-nan Li; Zhi-shan Liang; Zhi-yin Dai; Yi Mao; Qiu-tang Zeng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of medical research Volume: 40 ISSN: 1873-5487 ISO Abbreviation: Arch. Med. Res. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-07-17 Completed Date: 2009-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 285-93 Citation Subset: IM |
Affiliation:
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Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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immunology* Aged Angina, Unstable / immunology Down-Regulation / immunology Female Humans Interferon-gamma / immunology, metabolism Interleukin-4 / immunology Male Middle Aged T-Lymphocytes, Regulatory / immunology* Th1 Cells / immunology Th2 Cells / immunology Transforming Growth Factor beta1 / immunology |
| Chemical | |
Reg. No./Substance:
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0/Transforming Growth Factor beta1; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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