Document Detail


Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma.
MedLine Citation:
PMID:  21844183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease.
Authors:
Yan Li; Leilei Chen; Chang-jun Nie; Ting-ting Zeng; Haibo Liu; Xueying Mao; Yanru Qin; Ying-Hui Zhu; Li Fu; Xin-Yuan Guan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-15
Journal Detail:
Title:  Cancer research     Volume:  71     ISSN:  1538-7445     ISO Abbreviation:  Cancer Res.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-12-13     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6106-15     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Squamous Cell / genetics*,  pathology,  physiopathology
Cell Movement
Cell Proliferation
Cyclin-Dependent Kinase 4 / genetics
Down-Regulation
Esophageal Neoplasms / genetics*,  pathology,  physiopathology
Female
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Male
Mice
Mice, Nude
Middle Aged
Prognosis
Proto-Oncogene Proteins c-myc / genetics
RNA-Binding Proteins / genetics*
Trans-Activators / genetics*
Chemical
Reg. No./Substance:
0/MYC protein, human; 0/Proto-Oncogene Proteins c-myc; 0/RBMS3 protein, human; 0/RNA-Binding Proteins; 0/Trans-Activators; EC 2.7.11.22/CDK4 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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