| Downregulation of mouse intestinal Na(+)-coupled glucose transporter SGLT1 by gum arabic (Acacia Senegal). | |
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MedLine Citation:
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PMID: 20110681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal Na(+)-coupled glucose transporter SGLT1 determines the rate of glucose transport, which in turn influences glucose-induced insulin release and development of obesity. The present study explored effects of Gum Arabic (GA), a dietary polysaccharide from dried exudates of Acacia Senegal, on intestinal glucose transport and body weight in wild-type C57Bl/6 mice. Treatment with GA (100 g/l) in drinking water for four weeks did not affect intestinal SGLT1 transcript levels but decreased SGLT1 protein abundance in jejunal brush border membrane vesicles. Glucose-induced jejunal short-circuit currents revealed that GA treatment decreased electrogenic glucose transport. Drinking a 20% glucose solution for four weeks significantly increased body weight and fasting plasma glucose concentrations, effects significantly blunted by simultaneous treatment with GA. GA further significantly blunted the increase in body weight, fasting plasma glucose and fasting insulin concentrations during high fat diet. In conclusion, the present observations disclose a completely novel effect of gum arabic, i.e. its ability to decrease intestinal SGLT1 expression and activity and thus to counteract glucose-induced obesity. |
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Authors:
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Omaima Nasir; Ferruh Artunc; Kan Wang; Rexhep Rexhepaj; Michael F?ller; Ammar Ebrahim; Daniela S Kempe; Raja Biswas; Madhuri Bhandaru; Michael Walter; Nilufar Mohebbi; Carsten A Wagner; Amal M Saeed; Florian Lang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-12 |
Journal Detail:
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Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Volume: 25 ISSN: 1421-9778 ISO Abbreviation: Cell. Physiol. Biochem. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9113221 Medline TA: Cell Physiol Biochem Country: Switzerland |
Other Details:
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Languages: eng Pagination: 203-10 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Physiology, University of Tuebingen, 72076 Tuebingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Down-Regulation Glucose / metabolism Gum Arabic / pharmacology* Insulin / metabolism Jejunum / metabolism* Male Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Sodium / metabolism* Sodium-Glucose Transporter 1 / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Sodium-Glucose Transporter 1; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-23-5/Sodium; 9000-01-5/Gum Arabic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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