Document Detail


Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance.
MedLine Citation:
PMID:  23711387     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Erbin is ubiquitously expressed in normal epithelial tissues and constitutively associates with Her2 at the basolateral membranes in epithelial cells. The inhibitory role of Erbin in ERK signaling has been demonstrated. However, whether the expression of Erbin is altered in Her2-overexpressing breast cancer is unclear. There is little information regarding the function of Erbin in cancer progression. In the present study, we demonstrate that the level of Erbin is significantly downregulated or lost in breast cancer tissues. Erbin deficiency resulted in a dramatic enhancement in heregulin-induced AKT activation and overexpression of Erbin not only significantly decreased the intensity of heregulin-induced AKT phosphorylation but also shortened its duration in Her2-overexpressing breast cancer cells. Knockdown of Erbin remarkably promotes cell migration, induces invasive phenotype of breast cancer cells and antagonized the anti-proliferative effect of therapeutic antibody trastuzumab. Treatment with AKT inhibitor GDC0941 dramatically reversed the effects of Erbin knockdown on the cell migration and trastuzumab resistance, which is mainly mediated by aberrant activation of AKT. The data reveal that Erbin is a negative regulator of AKT activation and suggest that Erbin may play a role in breast cancer progression.
Authors:
Dan Liu; Ming Shi; Chenyang Duan; Hongyu Chen; Yabin Hu; Zhengyan Yang; Huijun Duan; Ning Guo
Related Documents :
24944677 - Clinicopathological roles of adiponectin and leptin receptors in endometrial carcinoma.
24856827 - Zinc finger and btb domain-containing protein 3 is essential for the growth of cancer c...
24047697 - The estrogen receptor α is the key regulator of the bifunctional role of foxo3a transcr...
22278937 - The power of dna double-strand break (dsb) repair testing to predict breast cancer susc...
8985927 - A comparison of high-energy oblique lung irradiation techniques.
12060497 - Axillary lymph node cellular immune response to her-2/neu peptides in patients with car...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-24
Journal Detail:
Title:  Molecular immunology     Volume:  56     ISSN:  1872-9142     ISO Abbreviation:  Mol. Immunol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  104-112     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pathology, Hebei Medical University, Shijiazhuang 050017, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  MDR-ABC transporters: biomarkers in rheumatoid arthritis.
Next Document:  Proteomic changes induced by histone demethylase JMJD3 in TNF alpha-treated human monocytic (THP-1) ...