Document Detail


Downregulation of cough by exercise and voluntary hyperpnea.
MedLine Citation:
PMID:  20047078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No information exists on the effects of hyperpnea on the sensory and cognitive aspects of coughing evoked by inhalation of tussigenic agents. The threshold for the cough reflex induced by inhalation of increasing concentrations of ultrasonically nebulized distilled water (fog), and the index of cough reflex sensitivity, was assessed in 12 healthy humans in control conditions, during exercise, and during voluntary isocapnic hyperventilation (VIH) to the same level as the exercise. The intensity of the urge-to-cough (UTC), a cognitive component of coughing, was also recorded throughout the trials. The log-log relationship between inhaled fog concentrations and the correspondingly evoked UTC values, an index of the perceptual magnitude of the UTC sensitivity, was also calculated. Cough appearance was always assessed audiovisually. At an exercise level of 80% of anaerobic threshold, the mean cough threshold was increased from a control value of 1.03 +/- 0.65 to 2.25 +/- 1.14 ml/min (p < 0.01), i.e., cough sensitivity was downregulated. With VIH, the mean (+/-SD) threshold increased from 1.03 +/- 0.65 to 2.42 +/- 1.16 ml/min (p < 0.01), a similar downregulation. With exercise and VIH compared with control, mean UTC values at cough threshold were not significantly changed: control, 3.83 +/- 1.11 cm; exercise, 3.12 +/- 0.82 cm; VIH, 4.08 +/- 1.67 cm. Since the slopes of the log fog concentration/log UTC value were approximately halved during exercise and VIH compared with control, the UTC sensitivity to fog was depressed (p < 0.01). The results indicate that the adjustments brought into action by exercise-induced or voluntary hyperventilation exert inhibitory influences on the sensory and cognitive components of fog-induced cough.
Authors:
Giovanni A Fontana
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Publication Detail:
Type:  Journal Article     Date:  2010-01-03
Journal Detail:
Title:  Lung     Volume:  188 Suppl 1     ISSN:  1432-1750     ISO Abbreviation:  Lung     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S95-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Florence, Viale GB Morgagni, 85, 50134, Firenze, Italy, g.fontana@dac.unifi.it.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerosols
Animals
Cough / physiopathology,  prevention & control*
Exercise / physiology*
Female
Humans
Hyperventilation / physiopathology*
Male
Nerve Fibers, Unmyelinated / physiology
Pulmonary Stretch Receptors / physiopathology
Rabbits
Reflex / physiology
Sensory Thresholds / physiology
Volition / physiology
Chemical
Reg. No./Substance:
0/Aerosols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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