Document Detail


Downregulation of Ca2+ signalling proteins in cardiac hypertrophy.
MedLine Citation:
PMID:  20440249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calcium (Ca2+) signaling plays an essential role in several functions of cardiac myocytes. Transient rises and reductions of cytosolic Ca2+, permitted by the sarcoplasmic reticulum Ca2+ ATPase and other proteins, control each cycle of contraction and relaxation. Prolonged rises of cytosolic Ca2+ are involved in transcriptional activation, including the hypertrophy program. Furthermore, activation of transcriptional pathways produced by excitation of membrane receptors and involving Protein Kinases C and D, calcineurin, mitogen-activated protein kinases and glycogen synthase kinase 3b, generate competitive recruitment of transcriptional factors whereby Ca2+ signaling proteins are downregulated in cardiac hypertrophy. This imbalance leads to defects of muscle contraction (i.e., systole) and relaxation (i.e., diastole), and ultimately cardiac failure. Extensive experimentation on gene transfer and gene deletion is under way to clarify the role of Ca2+ signaling proteins in cardiac hypertrophy and failure, and to evaluate the possibility of gene therapy. On the other hand, the need for pharmacological agents directed to function or transcription/expression of Ca2+ signaling proteins is emphasized, considering their easier delivery and wide population targeting.
Authors:
A M Prasad; G Inesi
Related Documents :
21232039 - Rosiglitazone inhibits kv4.3 potassium channels by open-channel block and acceleration ...
8178949 - Calcium signaling induced by bradykinin is synergistically enhanced by high k+ in ng108...
10070089 - Interstitial ca2+ undergoes dynamic changes sufficient to stimulate nerve-dependent ca2...
23119169 - Calcium signalling and liver regeneration.
9723189 - An infra-red light-transmitting aperture controller for use in single-cell fluorescence...
2010949 - Discrete phase of calcium excess in the process of deterioration in an individual rat m...
17485229 - Copper induces permeability transition through its interaction with the adenine nucleot...
21232039 - Rosiglitazone inhibits kv4.3 potassium channels by open-channel block and acceleration ...
2843189 - Alpha-2-adrenergic modulation of the parathyroid hormone-inhibition of phosphate uptake...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  58     ISSN:  0026-4725     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  193-204     Citation Subset:  IM    
Affiliation:
California Pacific Medical Center, Research Institute, San Francisco, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Calcium Signaling / physiology*
Cardiomegaly / drug therapy,  metabolism*
Down-Regulation*
Humans
Intracellular Signaling Peptides and Proteins / physiology
Grant Support
ID/Acronym/Agency:
R01 HL-69830/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Systematic quality control for management of ST elevation acute myocardial infarction in setting of ...
Next Document:  Left ventricular repolarization heterogeneity as an arrhythmic substrate in heart failure.