Document Detail


Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.
MedLine Citation:
PMID:  23299619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Helicobacter pylori induces less gastric inflammation in children than adults. Here we investigated whether this reduced inflammation involves dysregulated T helper type 17 (Th17) responses. H. pylori-infected children and adults in Santiago, Chile had similar levels of H. pylori colonization, proportions of bacteria containing cagA and s1/s2 vacA markers of virulence, and strain genotypes (predominantly hpEurope), but the children had significantly reduced levels of gastric inflammation and neutrophil infiltration. The reduced neutrophil accumulation in the infected children was accompanied by significantly fewer gastric Th17 cells and significantly lower levels of interleukin (IL)-17-specific mRNA and protein compared with the infected adults. The gastric mucosa of H. pylori-infected children also contained higher numbers of IL-10+ cells and increased levels of both IL-10 and Foxp3 mRNA compared with that of the infected adults. Thus, reduced gastric inflammation, including diminished neutrophil accumulation, in H. pylori-infected children compared with infected adults is likely due to downregulated gastric Th17/IL-17 responses as a consequence of enhanced mucosal regulatory T-cell activity in the children.
Authors:
C Serrano; S W Wright; D Bimczok; C L Shaffer; T L Cover; A Venegas; M G Salazar; L E Smythies; P R Harris; P D Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-09
Journal Detail:
Title:  Mucosal immunology     Volume:  6     ISSN:  1935-3456     ISO Abbreviation:  Mucosal Immunol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-19     Completed Date:  2014-04-01     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  101299742     Medline TA:  Mucosal Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  950-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Disease Progression
Female
Forkhead Transcription Factors / metabolism
Gastric Mucosa / immunology*
Gastritis / etiology,  immunology*
Gene Expression Regulation
Helicobacter Infections / complications,  immunology*
Helicobacter pylori / immunology*,  pathogenicity
Humans
Interleukin-10 / genetics,  metabolism
Interleukin-17 / genetics,  metabolism
Male
Middle Aged
Neutrophils / immunology*
T-Lymphocytes, Regulatory / immunology*
Th17 Cells / immunology*
Virulence Factors
Grant Support
ID/Acronym/Agency:
AI-83027/AI/NIAID NIH HHS; AI-83539/AI/NIAID NIH HHS; AI068009/AI/NIAID NIH HHS; C06 RR020136/RR/NCRR NIH HHS; CA116087/CA/NCI NIH HHS; DK-54495/DK/NIDDK NIH HHS; DK-64400/DK/NIDDK NIH HHS; DK-84063/DK/NIDDK NIH HHS; P01 AI083027/AI/NIAID NIH HHS; P01 CA116087/CA/NCI NIH HHS; R01 AI068009/AI/NIAID NIH HHS; R01 DK054495/DK/NIDDK NIH HHS; R01 DK084063/DK/NIDDK NIH HHS; R21 AI083539/AI/NIAID NIH HHS; R24 DK064400/DK/NIDDK NIH HHS; RR-20136/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Interleukin-17; 0/Virulence Factors; 130068-27-8/Interleukin-10
Comments/Corrections

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