Document Detail

Downbeat nystagmus as a result of lamotrigine toxicity.
MedLine Citation:
PMID:  15716057     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Downbeat nystagmus (DBN) has been reported with phenytoin and carbamazepine toxicity. DBN has not been described as a result of lamotrigine toxicity.
METHODS: Clinical records, neuroimaging and video recordings were obtained in two patients diagnosed with intractable epilepsy who developed oscillopsia and incoordination while being treated with lamotrigine. One patient had a videonystagmographic (VNG) study.
DISCUSSION: Lamotrigine's half-life is extended when used with valproic acid; hence, the increased chance of neurotoxicity associated with DBN. In our cases, DBN and truncal ataxia occurred in conjunction with toxic lamotrigine serum levels.
CONCLUSION: Anticonvulsant toxicity should be considered as a cause of DBN. Lamotrigine toxicity may be an unusual cause.
Ammar Alkawi; Jorge C Kattah; Katie Wyman
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-01-24
Journal Detail:
Title:  Epilepsy research     Volume:  63     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-06-24     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Department of Neurology, University of Illinois College of Medicine at Peoria, OSF Saint Francis Medical Center, 530N.E. Glen Oak Avenue, Peoria, IL 61637, USA.
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MeSH Terms
Anticonvulsants / blood,  toxicity*
Diagnostic Imaging / methods
Nystagmus, Pathologic / etiology*
Triazines / blood,  toxicity*
Video Recording / methods
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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