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Down syndrome with different hematological manifestations: a short series of 3 cases with review of literature.
MedLine Citation:
PMID:  24426330     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Children with Down syndrome (DS) present with a spectrum of hematolymphoid malignancies ranging from transient myeloproliferative disorder (TMD) which regress spontaneously to frank acute leukemia of both myeloid and lymphoid lineage. Here we present a series of three cases with different manifestation in DS. Three cases of DS presented with TMD, acute myeloid leukemia (AML-M2) and acute megakaryoblastic leukemia (AMKL), respectively. This case series displays the spectrum of hematological manifestations in children with DS. Although TMD and AMKL are strongly associated with DS, other AML subtypes can also be seen in such patients.
Authors:
Prabhu Manivannan; Priavadhana Rajan Prasaad; Rakhee Kar; Debdatta Basu
Publication Detail:
Type:  Journal Article     Date:  2012-02-01
Journal Detail:
Title:  Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion     Volume:  29     ISSN:  0971-4502     ISO Abbreviation:  Indian J Hematol Blood Transfus     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2014-01-15     Completed Date:  2014-01-15     Revised Date:  2014-03-03    
Medline Journal Info:
Nlm Unique ID:  9425818     Medline TA:  Indian J Hematol Blood Transfus     Country:  India    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  -    
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