| Down syndrome with congenital heart malformation. | |
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MedLine Citation:
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PMID: 138359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two hundred fifty-one patients with Down syndrome and congenital heart disease was based on clinical (41%), catheterization (38%), surgical (11%), or autopsy data (10%). The most common lesions were endocardial cushion defect (43%), ventricular septal defect (32%), secundum atrial septal defect (10%), tetralogy of Fallot (6%), and isolated patent ductus arteriosus (4%). Thirty percent had multiple cardiac defects. The most common associated lesions were patent ductus arteriosus (16%) and pulmonic stenosis (9%). Twenty-five percent of the patients uncerwent cardiac surgery. Motality in the 68 patients undergoing surgery was 26% for open heart procedures and 11% for closed heart surgery. In 32% of nonsurgically treated patients with large left-to-right shunts, irreversible pulmonary vascular disease developed. Improved medical and surgical care have decreased morbidity and mortality in these patients in recent years. |
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Authors:
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S C Park; R A Mathews; J R Zuberbuhler; R D Rowe; W H Neches; C C Lenox |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 131 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1977 Jan |
Date Detail:
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Created Date: 1977-03-15 Completed Date: 1977-03-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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diagnosis Adolescent Adult Child Child, Preschool Down Syndrome / complications* Ductus Arteriosus, Patent / complications Female Heart Defects, Congenital / complications*, mortality, surgery Heart Septal Defects / complications Heart Septal Defects, Atrial / complications Heart Septal Defects, Ventricular / complications Humans Infant Infant, Newborn Male Tetralogy of Fallot / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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