Document Detail

Down syndrome screening in women under 35 with maternal serum hCG.
MedLine Citation:
PMID:  1694288     Owner:  NLM     Status:  MEDLINE    
Human chorionic gonadotropin and maternal serum alpha-fetoprotein (MSAFP) concentrations were measured in frozen maternal serum samples from 16 pregnancies with Down syndrome and from 614 unaffected pregnancies in women younger than 35. By using only maternal age and MSAFP level to determine Down syndrome risk, four of 16 (25%) Down syndrome pregnancies were identified, using risk estimates as a screening variable. This detection rate required performing amniocentesis on 4.8% of pregnancies with a normal outcome. By adding hCG level as a third risk parameter, ten of 16 (62.5%) Down syndrome pregnancies were detected. To achieve this detection rate, 4.7% of women under 35 would be recommended for amniocentesis. These results indicate that the estimation of risk for Down syndrome based on the addition of maternal hCG level to MSAFP level and maternal age will substantially improve the detection rate for Down syndrome, with no change in the amniocentesis rate. These findings are in agreement with other studies that suggest that hCG is a valuable addition to screening programs for Down syndrome.
S F Suchy; M T Yeager
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  76     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-07-31     Completed Date:  1990-07-31     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  AIM; IM    
Greenwood Genetic Center, South Carolina.
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MeSH Terms
Chorionic Gonadotropin / blood*
Down Syndrome / prevention & control*
Mass Screening*
Maternal Age
Mathematical Computing
Pregnancy Trimester, Second
alpha-Fetoproteins / metabolism
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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