| Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists. | |
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MedLine Citation:
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PMID: 19467637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine changes in screening and performance of invasive diagnostic procedures for Down syndrome between 2001 and 2007. STUDY DESIGN: The Society for Maternal-Fetal Medicine members completed a survey in 2007 regarding screening tests and diagnostic procedures for Down syndrome. With the use of descriptive statistics, the chi(2) test, and the Student t test, responses from 2007 were compared with responses from a similar 2001 survey. RESULTS: Performance of first-trimester screening more than doubled from 2001-2007 (43.1% in 2001, 97.3% in 2007; P < .0001). Between 2001 and 2007, the use of the quad screen increased 10-fold (8.5% in 2001, 85.6% in 2007; P < .0001). There was an estimated 20% decrease in invasive diagnostic procedures that were performed in risk-positive women (53.7% in 2001, 34.2% in 2007; P < .0001). In 2007, the average fetal loss rates that were quoted by maternal-fetal medicine specialists after chorionic villous sampling was 1:160 and after an amniocentesis was 1:493. CONCLUSION: Down syndrome screening evolved from 2001-2007, with an increasing emphasis on first-trimester screening. With more efficacious screening, the number of invasive procedures has declined. |
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Authors:
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Yu Ming Victor Fang; Peter Benn; Winston Campbell; Jay Bolnick; Anne Marie Prabulos; James F X Egan |
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Publication Detail:
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Type: Journal Article Date: 2009-05-21 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 201 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-06 Completed Date: 2009-08-21 Revised Date: 2010-03-16 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 97.e1-5 Citation Subset: AIM; IM |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, CT, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis / trends Certification / statistics & numerical data Chorionic Villi Sampling / trends Down Syndrome / diagnosis*, ultrasonography Female Health Care Surveys Humans Obstetrics / standards Physician's Practice Patterns / statistics & numerical data*, trends Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Prenatal Diagnosis / trends* Ultrasonography, Prenatal United States |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2010 Mar;202(3):e13; author reply e13
[PMID:
20004883
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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