| Down syndrome risk calculation for a twin fetus taking account of the nuchal translucency in the co-twin. | |
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MedLine Citation:
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PMID: 20578258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to describe and illustrate a method for calculating fetus-specific Down syndrome risk in twins, allowing for between-fetus nuchal translucency (NT) correlation. METHODS: The between-fetus correlation coefficient of log NT, in multiples of the median, was estimated from a series of 325 unaffected twins after adjustment for sonographer bias. A bivariate log Gaussian model was used to calculate likelihood ratios for discordant and concordant Down syndrome. Applying these to the prior maternal age-specific risk yielded risks in monozygous and dizygous twins. The weighted average risk was then computed with weights relating to chorionicity, gender, assisted reproduction and ethnicity. The method was illustrated using examples. RESULTS: The correlation coefficient in unaffected pregnancies was 0.45 (P < 0.0001) and estimated to be 0.12 and 0.04 in discordant and concordant twins, respectively. The examples showed very large differences in the risks obtained when the extent of correlation in NT between fetuses is taken into account and when the measurements are treated as independent. CONCLUSION: Fetus-specific Down syndrome risks in twins should be calculated using its own NT value as well as that of the co-twin. |
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Authors:
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Howard Cuckle; Ron Maymon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 827-33 Citation Subset: IM |
Copyright Information:
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(c) 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10036, USA. hsc2121@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diseases in Twins
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ultrasonography* Down Syndrome / ultrasonography* Female Humans Likelihood Functions Male Maternal Age Nuchal Translucency Measurement* Pregnancy Risk |
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