Document Detail

Down syndrome prevention program in a population with an older maternal age.
MedLine Citation:
PMID:  7862374     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effect of a relatively high proportion of pregnant women 35 years and older on the efficacy of prenatal screening for Down syndrome. METHODS: We obtained information on normal and abnormal cytogenetic and maternal serum marker studies for 1990 and 1992 from all 11 public and two private cytogenetic laboratories operating in Israel. RESULTS: In the Jewish Israeli population, 16.2-17.1% of all pregnant women are at least 35 years old. Thus, prenatal testing of all pregnant women at least 35 years old could have identified 62.8-66.5% of all Down syndrome cases. Screening by maternal serum markers would classify 9.28% of pregnancies as being at high risk for Down syndrome (greater than 1:386 at birth). The percentage of Down syndrome cases detected prenatally increased from 78 of 147 (53%) to 123 of 163 (75%) as a result of the increased use of prenatal testing from 11.3% to 19.4% of all pregnancies in 1990 and 1992, respectively. CONCLUSIONS: In a population with a high proportion of mothers at least 35 years old, as in the Jewish population in Israel, screening by maternal serum markers instead of by maternal age alone would leave the Down syndrome detection rate unchanged, but would lower the amniocentesis rate from 16.2-17.1% to 9.28%. In addition to the reduction in the expected fetal loss as a result of post-amniocentesis spontaneous abortion, this policy would also pay the cost of maternal serum marker testing of the entire pregnant population.
M Shohat; C Legum; Y Romem; Z Borochowitz; G Bach; B Goldman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  85     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-03-23     Completed Date:  1995-03-23     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  AIM; IM    
Institute of Medical Genetics, Beilinson-Petah Tiqva, Israel.
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MeSH Terms
Down Syndrome / diagnosis,  epidemiology,  etiology,  prevention & control*
Israel / epidemiology
Mass Screening*
Maternal Age*
Population Surveillance
Pregnancy, High-Risk*
Prenatal Diagnosis*
Program Evaluation
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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