Document Detail


Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.
MedLine Citation:
PMID:  21120524     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Down syndrome (DS) patients have an increased risk of developing pulmonary hypertension (PH). Increased plasma levels of asymmetric dimethylarginine (ADMA) may contribute to vascular dysfunction in adults with idiopathic pulmonary hypertension. Our goal was to test the hypothesis that DS patients with PH have higher plasma levels of ADMA than DS patients without PH. DS patients with definitive PH (n = 6) and DS patients with no evidence of PH (n = 12) were studied. Plasma levels of arginine, ADMA, and nitrite/nitrate (NOx; stable metabolites of nitric oxide (NO)) were measured. Plasma arginine concentration was lower (p < 0.05) in PH patients (23 ± 11 μM) versus non-PH patients (46 ± 24 μM). Plasma ADMA concentration was higher (p < 0.005) in PH patients (18.0 ± 4.2 μM) versus non-PH patients (8.6 ± 5.9 μM). Plasma NOx was lower (p < 0.05) in PH patients (4.5 ± 1.7 μM) versus non-PH patients (8.5 ± 7.3 μM). These results are consistent with ADMA contributing to lower NO production in DS patients with PH and suggest that ADMA levels may be a potential biomarker for PH in DS patients.
Authors:
Clifford L Cua; Lynette K Rogers; Louis G Chicoine; Molly Augustine; Yi Jin; Patricia L Nash; Leif D Nelin
Related Documents :
5571834 - A combined clinical and histological assessment of survival of patients with hodgkin's ...
15977144 - Radioiodine treatment of hyperthyroidism in patients with low thyroid uptake.
21547094 - Intra-abdominal hypertension and gastrointestinal symptoms in mechanically ventilated p...
14715844 - Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medul...
630744 - Surgical treatment of infective endocarditis in hemodialysis patients.
9860294 - Evaluation of methylation analysis for diagnostic testing in 258 referrals suspected of...
Publication Detail:
Type:  Journal Article     Date:  2010-12-01
Journal Detail:
Title:  European journal of pediatrics     Volume:  170     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  859-63     Citation Subset:  IM    
Affiliation:
The Heart Center, Nationwide Children's Hospital-The Ohio State University, Columbus, OH, USA, clcua@hotmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Promoter CpG island hypermethylation during breast cancer progression.
Next Document:  Assessing pain in ventilated newborns and infants: validation of the Hartwig score.