Document Detail


Down syndrome in one of non-identical Nigerian twins: a case report.
MedLine Citation:
PMID:  17563974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Down syndrome (DS) or Trisomy 21 is the most frequent and best known Trisomy in humans. Mothers under 25 years of age are known to have the average risk of a DS pregnancy of 1:1600, rising to 1:350 at 35 and 1:40 at age 43. Twining in DS occurs at a rate of 1.2% of pregnancies with only 1/6th of both of the pairs having Trisomy 21. METHOD: A 4-week-old male, second twin, was admitted in the University of Port Harcourt Teaching Hospital (UPTH) due to fast breathing from birth, cough and poor weight gain. He was very pale, (haematocrit 18%), dyspnoeic and had mongoloid features. There were coarse crepitations in lung fields, a systolic murmur and an enlarged liver The diagnoses were Down syndrome, bronchopneumonia and congenital heart disease with failure. The mother was aged 22 years and the twin sister was normal. RESULT: He was promptly treated with oxygen, diuretics, and antibiotics but died within three hours of admission before blood transfusion could be offered. CONCLUSION: Down syndrome in twin pregnancy is very rare and, to our knowledge none has been reported in Nigeria. That this was a product of first pregnancy in a lady as young as 22 years makes an interesting reading.
Authors:
B E Otaigbe
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Publication Detail:
Type:  Case Reports; Journal Article; Twin Study    
Journal Detail:
Title:  Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria     Volume:  16     ISSN:  1115-2613     ISO Abbreviation:  Niger J Med     Publication Date:    2007 Jan-Mar
Date Detail:
Created Date:  2007-06-13     Completed Date:  2007-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888321     Medline TA:  Niger J Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  74-6     Citation Subset:  IM    
Affiliation:
Dept of Paediatrics, University of Port Harcourt Teaching Hospital Rivers State, Nigeria. barbiejoe64@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Down Syndrome / diagnosis*,  genetics
Fatal Outcome
Humans
Infant
Infant, Newborn
Male
Nigeria
Twins, Dizygotic*

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