Document Detail

Down-regulation of peroxisome proliferator-activated receptor-gamma gene expression by sphingomyelins.
MedLine Citation:
PMID:  11286999     Owner:  NLM     Status:  MEDLINE    
We recently demonstrated that the sphingomyelin (SM) content of adipocyte membranes was negatively correlated with the expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the subcutaneous adipose tissue of obese women with variable degrees of insulin resistance. We have now investigated whether SM really does have an impact on the expression of PPARgamma in 3T3-F442A adipocytes. Adding SM to the culture medium for 24 h caused a significant increase in SM content of adipocyte membranes and an acyl chain length-dependent decrease in the levels of PPARgamma mRNA and protein. The longer the acyl chain of the fatty acid of SM, the greater was the decrease in PPARgamma. These data suggest that the nature of the fatty acid is important in the regulation of PPARgamma by the SM pathway.
N Al-Makdissy; A Bianchi; M Younsi; E Picard; P Valet; N Martinet; M Dauça; M Donner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  493     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-05     Completed Date:  2001-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Laboratoire de Nutrition et Maladdies Métaboliques, EA 2402, Proliferateurs de Peroxisomes, Faculté de Médecine, Université Henri-Poincaré, 54505 Vandoeuvre les Nancy, France.
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MeSH Terms
3T3 Cells
Adipocytes / drug effects,  metabolism
Base Sequence
Cholesterol / metabolism
DNA Primers / genetics
Down-Regulation / drug effects
Insulin Resistance
Membrane Lipids / metabolism
Obesity / metabolism
Phospholipids / metabolism
RNA, Messenger / genetics,  metabolism
Receptors, Cytoplasmic and Nuclear / biosynthesis,  genetics*
Sphingomyelins / chemistry,  metabolism,  pharmacology*
Transcription Factors / biosynthesis,  genetics*
Reg. No./Substance:
0/DNA Primers; 0/Membrane Lipids; 0/Phospholipids; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Sphingomyelins; 0/Transcription Factors; 57-88-5/Cholesterol

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