Document Detail

Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2.
MedLine Citation:
PMID:  23142219     Owner:  NLM     Status:  MEDLINE    
Growing evidence indicates that some tumor suppressive miRNAs are subject to epigenetic modifications during carcinogenesis. Here, we found that a large miRNA cluster of C19MC was upregulated in HCC cells after combined treatment with DNA methylation inhibitor and histone deacetylase inhibitor. MiR-517a and miR-517c were strikingly different from the remaining 41 miRNAs in C19MC. Ectopic expression of MiR-517a and miR-517c inhibited cell proliferation by blocking G2/M transition, whereas down-regulation of miR-517a and miR-517c facilitated cell growth. We further showed Pyk2 is a target of miR-517a and miR-517c and both the miRNAs are downregulated in HCC samples. These data collectively suggest that down-regulation of both miR-517a and miR-517c contribute to HCC development through regulating Pyk2.
Rui-Fang Liu; Xiao Xu; Jian Huang; Qian-Lan Fei; Fei Chen; Yan-Dong Li; Ze-Guang Han
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-07
Journal Detail:
Title:  Cancer letters     Volume:  329     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-03-12     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  164-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Shanghai Institute of Digestive Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, 197 Rui-Jin II Road, Shanghai 200025, China.
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MeSH Terms
Azacitidine / analogs & derivatives,  pharmacology
Base Sequence
Carcinoma, Hepatocellular / enzymology,  genetics*,  pathology
Cell Line, Tumor
Cell Proliferation*
DNA Modification Methylases / antagonists & inhibitors
Focal Adhesion Kinase 2 / genetics*,  metabolism
G2 Phase Cell Cycle Checkpoints
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Histone Deacetylase Inhibitors / pharmacology
Hydroxamic Acids / pharmacology
Liver Neoplasms / enzymology,  genetics*,  pathology
MicroRNAs / genetics*,  metabolism,  physiology
Multigene Family
Oligonucleotide Array Sequence Analysis
RNA Interference
Reg. No./Substance:
0/Histone Deacetylase Inhibitors; 0/Hydroxamic Acids; 0/MIRN517 microRNA, human; 0/MicroRNAs; 320-67-2/Azacitidine; 3X2S926L3Z/trichostatin A; 776B62CQ27/decitabine; EC 2.1.1.-/DNA Modification Methylases; EC Adhesion Kinase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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