| Down-regulation of inhibition following unilateral deafening. | |
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MedLine Citation:
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PMID: 10962184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physiological and neurochemical experiments described here suggest that unilateral deafening causes a reduction in inhibition in the adult gerbil inferior colliculus (IC) contralateral to the deafened ear. Multiple-unit recordings were made from single electrode penetrations in the IC prior to and directly after contralateral cochlear ablation. These recordings showed up to 60% increases in the proportion of sampled loci at which neural activity excited by ipsilateral stimulation was observed after the ablation. Novel excitatory responses were evident within minutes of the ablation. Western blotting for glutamic acid decarboxylase protein levels showed significant decreases in the IC contralateral to cochlear ablation, relative to those in the ipsilateral IC, at 24 h and 7 days survival after the ablation. Four hour or 1 year survival post-ablation did not produce significant contralateral/ipsilateral differences in relation to the control group. Taken together, these results suggest the presence of at least two, short-term mechanisms involved in the central response to cochlear removal, both of which appear to implicate a decreased inhibitory influence. One is a very rapid, stimulus-related, functional unmasking. The other is a more delayed reduction in the capacity of gamma-aminobutyric acid synthesis in the IC. |
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Authors:
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J E Mossop; M J Wilson; D M Caspary; D R Moore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hearing research Volume: 147 ISSN: 0378-5955 ISO Abbreviation: Hear. Res. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-10-19 Completed Date: 2000-10-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7900445 Medline TA: Hear Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 183-7 Citation Subset: IM |
Affiliation:
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University Laboratory of Physiology, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cochlea / physiopathology Deafness / physiopathology* Down-Regulation Evoked Potentials, Auditory Gerbillinae Glutamate Decarboxylase / metabolism Inferior Colliculi / physiopathology* Neuronal Plasticity |
| Grant Support | |
ID/Acronym/Agency:
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DC00151/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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