Document Detail


Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants.
MedLine Citation:
PMID:  6546969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mouse thymoma-derived cell line W7 is sensitive to the cytolytic action of glucocorticoids. We have isolated a novel class of cell variant that apparently overcomes its inherent sensitivity to glucocorticoids by reversibly down-regulating the level of glucocorticoid receptors. This phenotype is stable during subcloning in the presence and in the absence of glucocorticoids and is dominant in somatic cell hybrids with wild-type cells. Fusion of this variant with wild-type cells produces hybrids that down-regulate and are less sensitive to glucocorticoids than hybrids of receptor-negative and wild-type cells. This is the first demonstration of a phenotypic change which correlates with down-regulation of the glucocorticoid receptor.
Authors:
M Danielsen; M R Stallcup
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and cellular biology     Volume:  4     ISSN:  0270-7306     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-06-06     Completed Date:  1984-06-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  449-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division / drug effects
Cell Line
Dexamethasone / metabolism,  pharmacology
Genetic Variation
Hybrid Cells / drug effects,  physiology
Lymphoma, Non-Hodgkin / physiopathology*
Mice
Receptors, Glucocorticoid / metabolism*
Receptors, Steroid / metabolism*
Thymoma / physiopathology*
Thymus Neoplasms / physiopathology*
Grant Support
ID/Acronym/Agency:
GM-28298/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Glucocorticoid; 0/Receptors, Steroid; 50-02-2/Dexamethasone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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