| Down-regulation of fragile histidine triad expression in prostate carcinoma. | |
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MedLine Citation:
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PMID: 12627509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The fragile histidine triad (FHIT) gene is a tumor suppressor gene that belongs to the histidine triad family of nucleoside binding proteins. The gene encompasses the common human chromosomal fragile site, the FRA3B locus at chromosome 3p14.2, and is expressed in most normal adult tissues and tumor cell lines. Numerous studies have indicated that the FHIT gene on chromosome 3p may play an important role in human neoplasia, although very few studies have investigated the FHIT gene in prostate carcinoma. METHODS: Using immunohistochemical analyses, the authors studied the expression of FHIT in prostate tumors from 84 radical prostatectomy specimens to determine whether there were any correlations between FHIT expression and various clinicopathologic characteristics. RESULTS: The percentages of cells stained with antibody to FHIT were significantly lower overall for tumor cells compared with normal cells (P = 0.0001). FHIT immunostaining intensity also was significantly lower for tumor cells compared with normal cells (P = 0.0001). A weak but statistically significant correlation (P = 0.045) was demonstrated with the presence of extraprostatic extension in the patient samples. No other significant correlation was seen between the percentage of cells stained for FHIT or FHIT immunostaining intensity and Gleason grade, tumor stage, tumor size, lymph node metastasis, surgical margins, vascular invasion, perineural invasion, or the presence of high-grade prostatic intraepithelial neoplasia. CONCLUSIONS: The data presented indicate a down-regulation of the FHIT tumor suppressor gene in prostate carcinoma and, thus, propose a potential target for therapeutic intervention. |
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Authors:
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Rebecca L Fouts; George E Sandusky; Shaobo Zhang; George J Eckert; Michael O Koch; Thomas M Ulbright; John N Eble; Liang Cheng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer Volume: 97 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-10 Completed Date: 2003-04-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1447-52 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11201 |
Affiliation:
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Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Anhydride Hydrolases Carcinoma / genetics*, pathology, surgery Down-Regulation Gene Expression Regulation, Neoplastic* Genes, Tumor Suppressor Humans Immunohistochemistry Male Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Proteins Neoplasm Staging Prognosis Prostatectomy Prostatic Neoplasms / genetics*, pathology, surgery Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/Tumor Markers, Biological; 0/fragile histidine triad protein; EC 3.6.-/Acid Anhydride Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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