Document Detail

Down regulation of bisphenol A glucuronidation in carp during the winter pre-breeding season.
MedLine Citation:
PMID:  16481053     Owner:  NLM     Status:  MEDLINE    
Environmental pollution by bisphenol A is prevalent in many rivers. The influence of bisphenol A on the reproductive organs of carp has been demonstrated to be serious, especially in the winter pre-breeding season. Although bisphenol A is detoxified as bisphenol A-glucuronide in carp organs, principally the intestine, the seasonal variation in the efficiency of the detoxification is not known. To estimate the seasonal risk of bisphenol A in carp, we investigated seasonal changes in microsomal UDP-glucuronosyltransferase activity toward bisphenol A in male-carp. Seasonal elimination efficiency of bisphenol A was also examined by organ perfusion in everted intestine. No marked seasonal differences were observed in UDP-glucuronosyltransferase activity toward 1-naphthol, but high activity toward sex steroid hormones (testosterone and estradiol) was observed in the winter pre-breeding season. Low UDP-glucuronosyltransferase activity toward bisphenol A was indicated in winter. The addition of bisphenol A into the mucosal fluid of the everted intestine resulted in excretion of bisphenol A into the mucosal side of the intestine as the metabolite, bisphenol A-glucuronide. Excretion of bisphenol A-glucuronide from carp intestine was highest in summer (proximal intestine: 13.3 nmol; middle intestine: 8.3 nmol; distal intestine: 7.9 nmol) and lowest in winter (proximal intestine: 1.0 nmol; middle intestine: 1.0 nmol; distal intestine: 0.9 nmol). These results suggest that metabolism and excretion of bisphenol A in carp hepatopancreas and intestine are impaired by down regulation of UDP-glucuronosyltransferase activity in the winter pre-breeding season.
Tomo Daidoji; Taeko Kaino; Hidetomo Iwano; Hiroki Inoue; Ryo Kurihara; Shinya Hashimoto; Hiroshi Yokota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-14
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  77     ISSN:  0166-445X     ISO Abbreviation:  Aquat. Toxicol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-02     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  386-92     Citation Subset:  IM    
Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582-1, Bunkyodai-Midorimachi, Ebetsui, 069-8501, Japan.
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MeSH Terms
Carps / metabolism*
Chromatography, High Pressure Liquid / veterinary
Estradiol / analysis,  metabolism
Estrogens, Non-Steroidal / analysis,  pharmacokinetics*
Glucuronides / metabolism
Glucuronosyltransferase / analysis,  metabolism
Hepatopancreas / metabolism
Intestines / metabolism
Metabolic Detoxication, Drug / physiology*
Microsomes / enzymology,  metabolism
Naphthols / analysis,  metabolism
Phenols / analysis,  pharmacokinetics*
Testosterone / analysis,  metabolism
Reg. No./Substance:
0/Estrogens, Non-Steroidal; 0/Glucuronides; 0/Naphthols; 0/Phenols; 50-28-2/Estradiol; 58-22-0/Testosterone; 80-05-7/bisphenol A; 90-15-3/1-naphthol; EC

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