| Down-regulation of apoptosis after left ventricular aneurysm repair. | |
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MedLine Citation:
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PMID: 17888983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Apoptosis is a common feature of the cardiomyopathic process contributing to progressive decline in ventricular function after transmural myocardial infarction. We hypothesized that left ventricular aneurysm repair (LVAR) down-regulates apoptotic potential of cardiomyocytes in the surviving myocardium. METHODS: In the rat infarct model, LV aneurysms were repaired by pursestring suture 2 weeks after coronary artery ligation. Cardiac function and myocardial infarction size were assessed by echocardiography and transverse heart sections, respectively, before sacrifice 12 weeks later. Cardiomyocytes and TdT-mediated dUTP terminal nick-end labeling (TUNEL) assays of apoptotic nuclei were analyzed adjacent to and remote from the aneurysm (8 in infarction group, 7 in aneurysm group, and 11 in repair group). Biochemical samples for immunoblot were also obtained from surviving myocardium. RESULTS: A statistically significant increase in apoptotic rate was seen in both adjacent and remote areas (p < 0.01) after aneurysm formation. After LVAR, heart function was improved, and TUNEL assays also show significant decrease when compared with aneurysm group. But significant decreases were noted only in activated caspase-9 and increases in Bcl-2 in immunoblot analysis when comparing repair group with aneurysm group. CONCLUSIONS: Down-regulation of apoptosis accounts for the change in the long-term benefit after LVAR. To prevent heart failure, LVAR is indicated when it is large enough, and the infarction area should be excluded as much as possible. |
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Authors:
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Chiao-Po Hsu; Chun-Yao Huang; Jih-Shiuan Wang; Hsin-I Chiang; Chun-Che Shih |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 84 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-24 Completed Date: 2007-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1279-87 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Apoptosis / physiology* Disease Models, Animal Down-Regulation* Female Heart Aneurysm / etiology, pathology, surgery* Heart Failure / prevention & control Heart Ventricles / pathology, surgery Immunoblotting Immunohistochemistry In Situ Nick-End Labeling Myocardial Infarction / complications Myocytes, Cardiac / pathology, physiology* Random Allocation Rats Rats, Sprague-Dawley Reference Values |
| Comments/Corrections | |
Comment In:
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Ann Thorac Surg. 2007 Oct;84(4):1287
[PMID:
17888984
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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