Document Detail


Down regulation of the angiotensin II receptor subtype AT2 in human myometrium during pregnancy.
MedLine Citation:
PMID:  7800857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Samples of human myometrium have been collected during pregnancy and from non-pregnant women. Binding studies revealed the presence of a 50-fold higher density of angiotensin II AT2 receptor in the non-pregnant state than during gestation. Low levels of the AT1 receptor subtype (approx. 20 fmol/mg protein) were detected in both pregnant and non-pregnant myometrium. Outside pregnancy, the AT2 receptor accounted for greater than 95% of all angiotensin receptors, whereas during pregnancy the value dropped to about 40%. The down regulation of the human myometrial AT2 receptor during pregnancy may be related to the high hormonal content of the environment induced by gestation. The mechanism by which the AT2 receptor is regulated appears to be different to that of the AT1 receptor.
Authors:
M de Gasparo; S Whitebread; M K Kalenga; R de Hertogh; P Crevoisier; K Thomas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Regulatory peptides     Volume:  53     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Department, Ciba-Geigy Ltd., Basle, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
1-Sarcosine-8-Isoleucine Angiotensin II / metabolism
Adult
Aged
Angiotensin II / metabolism
Binding, Competitive
Down-Regulation*
Female
Humans
Middle Aged
Myometrium / metabolism*
Pregnancy / metabolism*
Receptors, Angiotensin / metabolism*
Chemical
Reg. No./Substance:
0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 9088-01-1/1-Sarcosine-8-Isoleucine Angiotensin II
Comments/Corrections
Erratum In:
Regul Pept 1994 Oct 21;53(3):275

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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