| Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 20850384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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B cell tolerance is regulated by receptors that modulate B cell receptor signaling, such as Fc gamma receptor IIb (FcγRIIb; CD32b) and complement receptors (CR) 1 and 2. Deficiency in these receptors may contribute to autoimmunity. To address this we have investigated the receptor expression in healthy individuals in comparison with rheumatoid arthritis (RA) patients. In healthy subjects we found that women had overall lower FcγRIIb expression on B cells than men that significantly decreased with age. RA patients had fewer FcγRIIb, CR1 and CR2 positive B cells and decreased receptor expressions compared to healthy subjects. Further, the RA B cells displayed a significantly increased proliferative response when cultured with interleukin-2 in vitro. In summary, the dysregulated B cells in RA are associated with lower FcγRIIb, CR1 and CR2 levels. The reduced FcγRIIb expression on B cells in women may influence the increased frequency of autoimmunity in women. |
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Authors:
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Kajsa E Prokopec; Mia Rhodiner; Peter Matt; Ulla Lindqvist; Sandra Kleinau |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-17 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 137 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-11-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 322-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthritis, Rheumatoid / immunology* Autoimmunity* B-Lymphocytes / immunology* Cell Proliferation Disease Susceptibility Down-Regulation / immunology Female Humans Interleukin-2 / immunology Male Middle Aged Receptors, Complement 3b / deficiency, immunology* Receptors, Complement 3d / deficiency, immunology* Receptors, IgG / immunology*, metabolism* Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Fc gamma receptor IIB; 0/Interleukin-2; 0/Receptors, Complement 3b; 0/Receptors, Complement 3d; 0/Receptors, IgG |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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